KEGG   NETWORK: N00924
Entry
N00924                      Network                                

Name
Glucocorticoid receptor signaling pathway
Definition
GC -> NR3C1 -- MED14 => (IGFBP1,IRF8)
  Expanded
C00735 -> 2908 -- 9282 => (3484,3394)
Class
nt06310 CRH-ACTH-cortisol signaling
Type
Reference
Gene
2908  NR3C1; nuclear receptor subfamily 3 group C member 1
9282  MED14; mediator complex subunit 14
3484  IGFBP1; insulin like growth factor binding protein 1
3394  IRF8; interferon regulatory factor 8
Metabolite
C00735  Cortisol
Reference
  Authors
Oakley RH, Cidlowski JA
  Title
The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease.
  Journal
J Allergy Clin Immunol 132:1033-44 (2013)
DOI:10.1016/j.jaci.2013.09.007
Reference
  Authors
Kadmiel M, Cidlowski JA
  Title
Glucocorticoid receptor signaling in health and disease.
  Journal
Trends Pharmacol Sci 34:518-30 (2013)
DOI:10.1016/j.tips.2013.07.003
Reference
  Authors
Oakley RH, Cidlowski JA
  Title
Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids.
  Journal
J Biol Chem 286:3177-84 (2011)
DOI:10.1074/jbc.R110.179325
Reference
  Authors
Chen W, Dang T, Blind RD, Wang Z, Cavasotto CN, Hittelman AB, Rogatsky I, Logan SK, Garabedian MJ
  Title
Glucocorticoid receptor phosphorylation differentially affects target gene expression.
  Journal
Mol Endocrinol 22:1754-66 (2008)
DOI:10.1210/me.2007-0219
Reference
  Authors
Chen W, Rogatsky I, Garabedian MJ
  Title
MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor.
  Journal
Mol Endocrinol 20:560-72 (2006)
DOI:10.1210/me.2005-0318
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