KEGG   NETWORK: N00926
Entry
N00926                      Network                                

Name
Escherichia Tir to TLR2/4-MAPK signaling pathway
Definition
Tir -> SHP1/2 -| (TRAF6+TAK1+TAB2)
  Expanded
K12784 -> (5777+5781) -| (7189+6885+23118)
Class
nt06121 TLR signaling (viruses and bacteria)
Type
Pathogen
Pathway
hsa05130  Pathogenic Escherichia coli infection
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Gene
5777  PTPN6; protein tyrosine phosphatase non-receptor type 6
5781  PTPN11; protein tyrosine phosphatase non-receptor type 11
7189  TRAF6; TNF receptor associated factor 6
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Perturbant
K12784 (Tir)  tir; translocated intimin receptor
Reference
  Authors
Yan D, Wang X, Luo L, Cao X, Ge B
  Title
Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs.
  Journal
Nat Immunol 13:1063-71 (2012)
DOI:10.1038/ni.2417
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