KEGG   NETWORK: N00934
Entry
N00934                      Network                                

Name
Non-canonical inflammasome signaling pathway
Definition
LPS -> CASP4/5 -> (NLRP3+PYCARD+CASP1) -> (IL1B,IL18)
  Expanded
C00338 -> (837,838) -> (114548+29108+834) -> (3553,3606)
Class
nt06139 NLR signaling (viruses and bacteria)
Type
Reference
Pathway
hsa04621  NOD-like receptor signaling pathway
Gene
837  CASP4; caspase 4
838  CASP5; caspase 5
114548  NLRP3; NLR family pyrin domain containing 3
29108  PYCARD; PYD and CARD domain containing
834  CASP1; caspase 1
3553  IL1B; interleukin 1 beta
3606  IL18; interleukin 18
Metabolite
C00338  Lipopolysaccharide
Reference
  Authors
Yi YS
  Title
Regulatory Roles of the Caspase-11 Non-Canonical Inflammasome in Inflammatory Diseases.
  Journal
Immune Netw 18:e41 (2018)
DOI:10.4110/in.2018.18.e41
Reference
  Authors
Shi J, Zhao Y, Wang Y, Gao W, Ding J, Li P, Hu L, Shao F
  Title
Inflammatory caspases are innate immune receptors for intracellular LPS.
  Journal
Nature 514:187-92 (2014)
DOI:10.1038/nature13683
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