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Entry
N00936                      Network                                

Name
Escherichia NleB1 to crosstalk between extrinsic and intrinsic apoptotic pathways
Definition
bNleB1 -| FADD -> CASP8
  Expanded
K23657 -| 8772 -> 841
Class
nt06131 Apoptosis (viruses and bacteria)
Type
Pathogen
Pathway
hsa05130  Pathogenic Escherichia coli infection
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Gene
8772  FADD; Fas associated via death domain
841  CASP8; caspase 8
Perturbant
K23657  nleB; T3SS secreted effector NleB
Reference
  Authors
Li S, Zhang L, Yao Q, Li L, Dong N, Rong J, Gao W, Ding X, Sun L, Chen X, Chen S, Shao F
  Title
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.
  Journal
Nature 501:242-6 (2013)
DOI:10.1038/nature12436
Reference
  Authors
Pearson JS, Giogha C, Ong SY, Kennedy CL, Kelly M, Robinson KS, Lung TW, Mansell A, Riedmaier P, Oates CV, Zaid A, Muhlen S, Crepin VF, Marches O, Ang CS, Williamson NA, O'Reilly LA, Bankovacki A, Nachbur U, Infusini G, Webb AI, Silke J, Strasser A, Frankel G, Hartland EL
  Title
A type III effector antagonizes death receptor signalling during bacterial gut infection.
  Journal
Nature 501:247-51 (2013)
DOI:10.1038/nature12524
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