KEGG   NETWORK: N00938Help
Entry
N00938                      Network                                

Name
Escherichia NleH to intrinsic apoptotic pathway
Definition
bNleH -> TMBIM6 -| BAX
  Expanded
K16042 -> 7009 -| 581
Class
nt06131 Apoptosis (viruses and bacteria)
Type
Pathogen
Pathway
hsa05130  Pathogenic Escherichia coli infection
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Gene
7009  TMBIM6; transmembrane BAX inhibitor motif containing 6
581  BAX; BCL2 associated X, apoptosis regulator
Perturbant
K16042  nleH; non-LEE-encoded effector NleH
Reference
  Authors
Hemrajani C, Berger CN, Robinson KS, Marches O, Mousnier A, Frankel G
  Title
NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection.
  Journal
Proc Natl Acad Sci U S A 107:3129-34 (2010)
DOI:10.1073/pnas.0911609106
Reference
  Authors
Ashida H, Mimuro H, Ogawa M, Kobayashi T, Sanada T, Kim M, Sasakawa C
  Title
Cell death and infection: a double-edged sword for host and pathogen survival.
  Journal
J Cell Biol 195:931-42 (2011)
DOI:10.1083/jcb.201108081
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