KEGG   NETWORK: N00940
Entry
N00940                      Network                                

Name
NOD-NFKB signaling pathway
Definition
(NOD1,NOD2) -> RIPK2 -> IKK -> NFKBIA -> NFKB
  Expanded
(10392,64127) -> 8767 -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06139 NLR signaling (viruses and bacteria)
Type
Reference
Pathway
hsa04621  NOD-like receptor signaling pathway
Gene
10392  NOD1; nucleotide binding oligomerization domain containing 1
64127  NOD2; nucleotide binding oligomerization domain containing 2
8767  RIPK2; receptor interacting serine/threonine kinase 2
1147  CHUK; component of inhibitor of nuclear factor kappa B kinase complex
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Reference
  Authors
Moreira LO, Zamboni DS
  Title
NOD1 and NOD2 Signaling in Infection and Inflammation.
  Journal
Front Immunol 3:328 (2012)
DOI:10.3389/fimmu.2012.00328
Reference
  Authors
Negroni A, Pierdomenico M, Cucchiara S, Stronati L
  Title
NOD2 and inflammation: current insights.
  Journal
J Inflamm Res 11:49-60 (2018)
DOI:10.2147/JIR.S137606
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