KEGG   NETWORK: N00942
Entry
N00942                      Network                                

Name
Shigella OspG to TNF-NFKB signaling pathway
Definition
OspG -| (UBE2D2+(RBX1+CUL1+SKP1)+FBXW1/11) -> NFKBIA
  Expanded
K13792 -| (7322+(9978+8454+6500)+(23291,8945)) -> 4792
Class
nt06123 TNF signaling (viruses and bacteria)
Type
Pathogen
Pathway
hsa05131  Shigellosis
Disease
H00299  Shigellosis
Gene
7322  UBE2D2; ubiquitin conjugating enzyme E2 D2
9978  RBX1; ring-box 1
8454  CUL1; cullin 1
6500  SKP1; S-phase kinase associated protein 1
23291  FBXW11; F-box and WD repeat domain containing 11
8945  BTRC; beta-transducin repeat containing E3 ubiquitin protein ligase
4792  NFKBIA; NFKB inhibitor alpha
Perturbant
K13792 (OspG)  ospG; secreted effector OspG
Reference
  Authors
Kim DW, Lenzen G, Page AL, Legrain P, Sansonetti PJ, Parsot C
  Title
The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes.
  Journal
Proc Natl Acad Sci U S A 102:14046-51 (2005)
DOI:10.1073/pnas.0504466102
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