KEGG   NETWORK: N00951
Entry
N00951                      Network                                

Name
ITGA/B-RHOG-RAC signaling pathway
Definition
FN1 -> (ITGA+ITGB) -> RHOG -> (DOCK1+ELMO) -> RAC
  Expanded
2335 -> ((3672,3673,3674,3675,3676,3678,3679,8516,3680,8515,22801,3685)+(3688,3690,3691,3693,3694,3695,3696)) -> 391 -> (1793+(9844,63916,79767)) -> (5879,5880,5881)
Class
nt06135 Cytoskeletal regulation (viruses and bacteria)
Type
Reference
Gene
2335  FN1; fibronectin 1
3672  ITGA1; integrin subunit alpha 1
3673  ITGA2; integrin subunit alpha 2
3674  ITGA2B; integrin subunit alpha 2b
3675  ITGA3; integrin subunit alpha 3
3676  ITGA4; integrin subunit alpha 4
3678  ITGA5; integrin subunit alpha 5
3679  ITGA7; integrin subunit alpha 7
8516  ITGA8; integrin subunit alpha 8
3680  ITGA9; integrin subunit alpha 9
8515  ITGA10; integrin subunit alpha 10
22801  ITGA11; integrin subunit alpha 11
3685  ITGAV; integrin subunit alpha V
3688  ITGB1; integrin subunit beta 1
3690  ITGB3; integrin subunit beta 3
3691  ITGB4; integrin subunit beta 4
3693  ITGB5; integrin subunit beta 5
3694  ITGB6; integrin subunit beta 6
3695  ITGB7; integrin subunit beta 7
3696  ITGB8; integrin subunit beta 8
391  RHOG; ras homolog family member G
1793  DOCK1; dedicator of cytokinesis 1
9844  ELMO1; engulfment and cell motility 1
63916  ELMO2; engulfment and cell motility 2
79767  ELMO3; engulfment and cell motility 3
5879  RAC1; Rac family small GTPase 1
5880  RAC2; Rac family small GTPase 2
5881  RAC3; Rac family small GTPase 3
Reference
  Authors
Katoh H, Negishi M
  Title
RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo.
  Journal
Nature 424:461-4 (2003)
DOI:10.1038/nature01817
Reference
  Authors
Lawson CD, Burridge K
  Title
The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration.
  Journal
Small GTPases 5:e27958 (2014)
DOI:10.4161/sgtp.27958
Reference
  Authors
Guan X, Guan X, Dong C, Jiao Z
  Title
Rho GTPases and related signaling complexes in cell migration and invasion.
  Journal
Exp Cell Res 388:111824 (2020)
DOI:10.1016/j.yexcr.2020.111824
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