KEGG   NETWORK: N00953
Entry
N00953                      Network                                

Name
mGluR1-TRPC3 signaling pathway
Definition
Glutamate -> GRM1 -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -> PKC -| TRPC3 -> Ca2+
  Expanded
C00025 -> 2911 -> 2776 -> (23236,5330,5331,5332) -> C01245 -> (3708,3709,3710) -> C00076 -> (5578,5579,5582) -| 7222 -> C00076
Class
nt06410 Calcium signaling
nt06463 Parkinson disease
nt06462 Spinocerebellar ataxia
Type
Reference
Pathway
hsa04724  Glutamatergic synapse
hsa04730  Long-term depression
Gene
2911  GRM1; glutamate metabotropic receptor 1
2776  GNAQ; G protein subunit alpha q
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
3708  ITPR1; inositol 1,4,5-trisphosphate receptor type 1
3709  ITPR2; inositol 1,4,5-trisphosphate receptor type 2
3710  ITPR3; inositol 1,4,5-trisphosphate receptor type 3
5578  PRKCA; protein kinase C alpha
5579  PRKCB; protein kinase C beta
5582  PRKCG; protein kinase C gamma
7222  TRPC3; transient receptor potential cation channel subfamily C member 3
Metabolite
C00025  L-Glutamate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
C00076  Calcium cation
Reference
  Authors
Kano M, Watanabe T
  Title
Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease.
  Journal
F1000Res 6:416 (2017)
DOI:10.12688/f1000research.10485.1
Reference
  Authors
Becker EB
  Title
The Moonwalker mouse: new insights into TRPC3 function, cerebellar development, and ataxia.
  Journal
Cerebellum 13:628-36 (2014)
DOI:10.1007/s12311-014-0564-5
Reference
  Authors
Venkatachalam K, Zheng F, Gill DL
  Title
Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C.
  Journal
J Biol Chem 278:29031-40 (2003)
DOI:10.1074/jbc.M302751200
Reference
  Authors
Trebak M, Hempel N, Wedel BJ, Smyth JT, Bird GS, Putney JW Jr
  Title
Negative regulation of TRPC3 channels by protein kinase C-mediated phosphorylation of serine 712.
  Journal
Mol Pharmacol 67:558-63 (2005)
DOI:10.1124/mol.104.007252
LinkDB

DBGET integrated database retrieval system