KEGG   NETWORK: N00963
Entry
N00963                      Network                                

Name
RELN-VLDLR-PI3K signaling pathway
Definition
RELN -> VLDLR -- DAB1 -> PI3K -> PIP3 -> AKT -| (TSC1+TSC2) -| RHEB -> MTOR -> S6K
  Expanded
5649 -> 7436 -- 1600 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| (7248+7249) -| 6009 -> 2475 -> (6198,6199)
Class
nt06415 PI3K signaling
nt06462 Spinocerebellar ataxia
Type
Reference
Gene
5649  RELN; reelin
7436  VLDLR; very low density lipoprotein receptor
1600  DAB1; DAB adaptor protein 1
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
7248  TSC1; TSC complex subunit 1
7249  TSC2; TSC complex subunit 2
6009  RHEB; Ras homolog, mTORC1 binding
2475  MTOR; mechanistic target of rapamycin kinase
6198  RPS6KB1; ribosomal protein S6 kinase B1
6199  RPS6KB2; ribosomal protein S6 kinase B2
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Jossin Y, Goffinet AM
  Title
Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth.
  Journal
Mol Cell Biol 27:7113-24 (2007)
DOI:10.1128/MCB.00928-07
Reference
  Authors
Lee GH, D'Arcangelo G
  Title
New Insights into Reelin-Mediated Signaling Pathways.
  Journal
Front Cell Neurosci 10:122 (2016)
DOI:10.3389/fncel.2016.00122
LinkDB

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