KEGG   NETWORK: N00964
Entry
N00964                      Network                                

Name
DAB1-overexpression to RELN-VLDLR-PI3K signaling pathway
Definition
RELN -> VLDLR -- DAB1* -> PI3K -> PIP3 -> AKT
  Expanded
5649 -> 7436 -- 1600v1 -> (5290,5291,5293) -> C05981 -> (207,208,10000)
Class
nt06415 PI3K signaling
nt06462 Spinocerebellar ataxia
Type
Variant
Pathway
hsa05017  Spinocerebellar ataxia
Disease
H00063  Spinocerebellar ataxia (SCA)
Gene
5649  RELN; reelin
7436  VLDLR; very low density lipoprotein receptor
1600  DAB1; DAB adaptor protein 1
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Variant
1600v1 (DAB1*)  DAB1 overexpression
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Corral-Juan M, Serrano-Munuera C, Rabano A, Cota-Gonzalez D, Segarra-Roca A, Ispierto L, Cano-Orgaz AT, Adarmes AD, Mendez-Del-Barrio C, Jesus S, Mir P, Volpini V, Alvarez-Ramo R, Sanchez I, Matilla-Duenas A
  Title
Clinical, genetic and neuropathological characterization of spinocerebellar ataxia type 37.
  Journal
Brain 141:1981-1997 (2018)
DOI:10.1093/brain/awy137
Reference
  Authors
Matilla-Duenas A, Volpini V
  Title
Spinocerebellar Ataxia Type 37
  Journal
(1993)
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