KEGG   NETWORK: N00967
Entry
N00967                      Network                                

Name
VGCC-Ca2+ -apoptotic pathway
Definition
Ca2+(extracellular) -- VGCC -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS -- APAF1 -> CASP9 -> (CASP3,CASP7)
  Expanded
C00076 -- (779,775,776,778,773,774,777,8913,8912,8911) -> C00076 -- 90550 -> C00076 -- (7416,7417,7419,291,292,293,83447) -> 54205 -- 317 -> 842 -> (836,840)
Class
nt06410 Calcium signaling
nt06460 Alzheimer disease
nt06463 Parkinson disease
nt06461 Huntington disease
nt06462 Spinocerebellar ataxia
nt06465 Prion disease
Type
Reference
Pathway
hsa04724  Glutamatergic synapse
Gene
779  CACNA1S; calcium voltage-gated channel subunit alpha1 S
775  CACNA1C; calcium voltage-gated channel subunit alpha1 C
776  CACNA1D; calcium voltage-gated channel subunit alpha1 D
778  CACNA1F; calcium voltage-gated channel subunit alpha1 F
773  CACNA1A; calcium voltage-gated channel subunit alpha1 A
774  CACNA1B; calcium voltage-gated channel subunit alpha1 B
777  CACNA1E; calcium voltage-gated channel subunit alpha1 E
8913  CACNA1G; calcium voltage-gated channel subunit alpha1 G
8912  CACNA1H; calcium voltage-gated channel subunit alpha1 H
8911  CACNA1I; calcium voltage-gated channel subunit alpha1 I
90550  MCU; mitochondrial calcium uniporter
7416  VDAC1; voltage dependent anion channel 1
7417  VDAC2; voltage dependent anion channel 2
7419  VDAC3; voltage dependent anion channel 3
291  SLC25A4; solute carrier family 25 member 4
292  SLC25A5; solute carrier family 25 member 5
293  SLC25A6; solute carrier family 25 member 6
83447  SLC25A31; solute carrier family 25 member 31
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
840  CASP7; caspase 7
Metabolite
C00076  Calcium cation
C00076  Calcium cation
C00076  Calcium cation
Reference
  Authors
Catterall WA
  Title
Voltage-gated calcium channels.
  Journal
Cold Spring Harb Perspect Biol 3:a003947 (2011)
DOI:10.1101/cshperspect.a003947
Reference
  Authors
Catterall WA, Lenaeus MJ, Gamal El-Din TM
  Title
Structure and Pharmacology of Voltage-Gated Sodium and Calcium Channels.
  Journal
Annu Rev Pharmacol Toxicol 60:133-154 (2020)
DOI:10.1146/annurev-pharmtox-010818-021757
Reference
  Authors
Kondratskyi A, Kondratska K, Skryma R, Prevarskaya N
  Title
Ion channels in the regulation of apoptosis.
  Journal
Biochim Biophys Acta 1848:2532-46 (2015)
DOI:10.1016/j.bbamem.2014.10.030
Reference
  Authors
Giorgi C, Danese A, Missiroli S, Patergnani S, Pinton P
  Title
Calcium Dynamics as a Machine for Decoding Signals.
  Journal
Trends Cell Biol 28:258-273 (2018)
DOI:10.1016/j.tcb.2018.01.002
Reference
  Authors
Bahar E, Kim H, Yoon H
  Title
ER Stress-Mediated Signaling: Action Potential and Ca(2+) as Key Players.
  Journal
Int J Mol Sci 17:E1558 (2016)
DOI:10.3390/ijms17091558
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