KEGG   NETWORK: N00979
Entry
N00979                      Network                                

Name
Mutation-caused aberrant Htt to anterograde axonal transport
Definition
HTT* -> JNK3 -| (KIF5+KLC) -- (TUBA+TUBB)
  Expanded
3064v1 -> 5602 -| ((3798,3799,3800)+(3831,64837,147700,89953)) -- ((7846,10376,84790,7278,113457,112714,7277,51807)+(203068,81027,7280,347733,10381,10382,10383,84617,347688))
Class
nt06419 Microtubule-based transport
nt06461 Huntington disease
Type
Variant
Pathway
hsa05016  Huntington disease
Disease
H00059  Huntington disease
Gene
3064  HTT; huntingtin
5602  MAPK10; mitogen-activated protein kinase 10
3798  KIF5A; kinesin family member 5A
3799  KIF5B; kinesin family member 5B
3800  KIF5C; kinesin family member 5C
3831  KLC1; kinesin light chain 1
64837  KLC2; kinesin light chain 2
147700  KLC3; kinesin light chain 3
89953  KLC4; kinesin light chain 4
7846  TUBA1A; tubulin alpha 1a
10376  TUBA1B; tubulin alpha 1b
84790  TUBA1C; tubulin alpha 1c
7278  TUBA3C; tubulin alpha 3c
113457  TUBA3D; tubulin alpha 3d
112714  TUBA3E; tubulin alpha 3e
7277  TUBA4A; tubulin alpha 4a
51807  TUBA8; tubulin alpha 8
203068  TUBB; tubulin beta class I
81027  TUBB1; tubulin beta 1 class VI
7280  TUBB2A; tubulin beta 2A class IIa
347733  TUBB2B; tubulin beta 2B class IIb
10381  TUBB3; tubulin beta 3 class III
10382  TUBB4A; tubulin beta 4A class IVa
10383  TUBB4B; tubulin beta 4B class IVb
84617  TUBB6; tubulin beta 6 class V
347688  TUBB8; tubulin beta 8 class VIII
Variant
3064v1 (HTT*)  HTT mutation
Reference
  Authors
Millecamps S, Julien JP
  Title
Axonal transport deficits and neurodegenerative diseases.
  Journal
Nat Rev Neurosci 14:161-76 (2013)
DOI:10.1038/nrn3380
Reference
  Authors
Coffey ET
  Title
Nuclear and cytosolic JNK signalling in neurons.
  Journal
Nat Rev Neurosci 15:285-99 (2014)
DOI:10.1038/nrn3729
Reference
  Authors
Morfini GA, You YM, Pollema SL, Kaminska A, Liu K, Yoshioka K, Bjorkblom B, Coffey ET, Bagnato C, Han D, Huang CF, Banker G, Pigino G, Brady ST
  Title
Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.
  Journal
Nat Neurosci 12:864-71 (2009)
DOI:10.1038/nn.2346
Reference
  Authors
Duncan JE, Goldstein LS
  Title
The genetics of axonal transport and axonal transport disorders.
  Journal
PLoS Genet 2:e124 (2006)
DOI:10.1371/journal.pgen.0020124
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