KEGG   NETWORK: N00983
Entry
N00983                      Network                                

Name
Mutation-caused aberrant Htt to extrinsic apoptotic pathway
Definition
HTT* // (HIP1+IFT57) -> CASP8 -> CASP3
  Expanded
3064v1 // (3092+55081) -> 841 -> 836
Class
nt06414 Apoptosis
nt06461 Huntington disease
Type
Variant
Pathway
hsa05016  Huntington disease
Disease
H00059  Huntington disease
Gene
3064  HTT; huntingtin
3092  HIP1; huntingtin interacting protein 1
55081  IFT57; intraflagellar transport 57
841  CASP8; caspase 8
836  CASP3; caspase 3
Variant
3064v1 (HTT*)  HTT mutation
Reference
  Authors
Mattson MP.
  Title
Accomplices to neuronal death.
  Journal
Nature 415:377-9 (2002)
DOI:10.1038/415377a
Reference
  Authors
Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW.
  Title
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.
  Journal
Nat Cell Biol 4:95-105 (2002)
DOI:10.1038/ncb735
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