KEGG   NETWORK: N00984
Entry
N00984                      Network                                

Name
mGluR5-Ca2+ -apoptotic pathway
Definition
Glutamate -> GRM5 -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS -- APAF1 -> CASP9 -> (CASP3,CASP7)
  Expanded
C00025 -> 2915 -> 2776 -> (23236,5330,5331,5332) -> C01245 -> (3708,3709,3710) -> C00076 -- 90550 -> C00076 -- (7416,7417,7419,291,292,293,83447) -> 54205 -- 317 -> 842 -> (836,840)
Class
nt06410 Calcium signaling
nt06460 Alzheimer disease
nt06464 Amyotrophic lateral sclerosis
nt06461 Huntington disease
nt06462 Spinocerebellar ataxia
nt06465 Prion disease
Type
Reference
Pathway
hsa04724  Glutamatergic synapse
hsa04210  Apoptosis
hsa04720  Long-term potentiation
Gene
2915  GRM5; glutamate metabotropic receptor 5
2776  GNAQ; G protein subunit alpha q
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
3708  ITPR1; inositol 1,4,5-trisphosphate receptor type 1
3709  ITPR2; inositol 1,4,5-trisphosphate receptor type 2
3710  ITPR3; inositol 1,4,5-trisphosphate receptor type 3
90550  MCU; mitochondrial calcium uniporter
7416  VDAC1; voltage dependent anion channel 1
7417  VDAC2; voltage dependent anion channel 2
7419  VDAC3; voltage dependent anion channel 3
291  SLC25A4; solute carrier family 25 member 4
292  SLC25A5; solute carrier family 25 member 5
293  SLC25A6; solute carrier family 25 member 6
83447  SLC25A31; solute carrier family 25 member 31
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
840  CASP7; caspase 7
Metabolite
C00025  L-Glutamate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
C00076  Calcium cation
Reference
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
  Authors
Sushma, Mondal AC
  Title
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease.
  Journal
Mol Cell Neurosci 101:103414 (2019)
DOI:10.1016/j.mcn.2019.103414
Reference
  Authors
Penna E, Espino J, De Stefani D, Rizzuto R
  Title
The MCU complex in cell death.
  Journal
Cell Calcium 69:73-80 (2018)
DOI:10.1016/j.ceca.2017.08.008
Reference
  Authors
Giorgi C, Danese A, Missiroli S, Patergnani S, Pinton P
  Title
Calcium Dynamics as a Machine for Decoding Signals.
  Journal
Trends Cell Biol 28:258-273 (2018)
DOI:10.1016/j.tcb.2018.01.002
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