KEGG   NETWORK: N00992
Entry
N00992                      Network                                

Name
Mutation-caused aberrant Htt to TNF-JNK signaling pathway
Definition
HTT* -> MLK2 -> MKK7 -> JNK
  Expanded
3064v1 -> 4294 -> 5609 -> (5599,5601,5602)
Class
nt06416 TNF signaling
nt06461 Huntington disease
Type
Variant
Pathway
hsa05016  Huntington disease
Disease
H00059  Huntington disease
Gene
3064  HTT; huntingtin
4294  MAP3K10; mitogen-activated protein kinase kinase kinase 10
5609  MAP2K7; mitogen-activated protein kinase kinase 7
5599  MAPK8; mitogen-activated protein kinase 8
5601  MAPK9; mitogen-activated protein kinase 9
5602  MAPK10; mitogen-activated protein kinase 10
Variant
3064v1 (HTT*)  HTT mutation
Reference
  Authors
Borrell-Pages M, Zala D, Humbert S, Saudou F
  Title
Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.
  Journal
Cell Mol Life Sci 63:2642-60 (2006)
DOI:10.1007/s00018-006-6242-0
Reference
  Authors
Bowles KR, Jones L
  Title
Kinase signalling in Huntington's disease.
  Journal
J Huntingtons Dis 3:89-123 (2014)
DOI:10.3233/JHD-140106
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