KEGG   NETWORK: N01002
Entry
N01002                      Network                                

Name
Mutation-caused aberrant Abeta to mGluR5-Ca2+ -apoptotic pathway
Definition
APP* -> Abeta -> GRM5 -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS -- APAF1 -> CASP9 -> CASP3
  Expanded
351v1 -> (C16515,C16514) -> 2915 -> 2776 -> (23236,5330,5331,5332) -> C01245 -> (3708,3709,3710) -> C00076 -- 90550 -> C00076 -- (7416,7417,7419,291,292,293,83447) -> 54205 -- 317 -> 842 -> 836
Class
nt06410 Calcium signaling
nt06460 Alzheimer disease
Type
Variant
Pathway
hsa05010  Alzheimer disease
Disease
H00056  Alzheimer disease
Gene
351  APP; amyloid beta precursor protein
2915  GRM5; glutamate metabotropic receptor 5
2776  GNAQ; G protein subunit alpha q
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
3708  ITPR1; inositol 1,4,5-trisphosphate receptor type 1
3709  ITPR2; inositol 1,4,5-trisphosphate receptor type 2
3710  ITPR3; inositol 1,4,5-trisphosphate receptor type 3
90550  MCU; mitochondrial calcium uniporter
7416  VDAC1; voltage dependent anion channel 1
7417  VDAC2; voltage dependent anion channel 2
7419  VDAC3; voltage dependent anion channel 3
291  SLC25A4; solute carrier family 25 member 4
292  SLC25A5; solute carrier family 25 member 5
293  SLC25A6; solute carrier family 25 member 6
83447  SLC25A31; solute carrier family 25 member 31
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
Variant
351v1 (APP*)  APP mutation
Metabolite
C16515  Beta-amyloid protein 42
C16514  Beta-amyloid protein 40
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
C00076  Calcium cation
Reference
  Authors
Kim DI, Lee KH, Oh JY, Kim JS, Han HJ
  Title
Relationship Between beta-Amyloid and Mitochondrial Dynamics.
  Journal
Cell Mol Neurobiol 37:955-968 (2017)
DOI:10.1007/s10571-016-0434-4
Reference
  Authors
Popugaeva E, Pchitskaya E, Bezprozvanny I
  Title
Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.
  Journal
Antioxid Redox Signal 29:1176-1188 (2018)
DOI:10.1089/ars.2018.7506
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