KEGG   NETWORK: N01017
Entry
N01017                      Network                                

Name
Mutation-caused aberrant PSEN1 to anterograde axonal transport
Definition
PSEN1* -> GSK3B -| (KIF5+KLC)
  Expanded
5663v1 -> 2932 -| ((3798,3799,3800)+(3831,64837,147700,89953))
Class
nt06419 Microtubule-based transport
nt06460 Alzheimer disease
Type
Variant
Pathway
hsa05010  Alzheimer disease
Disease
H00056  Alzheimer disease
Gene
5663  PSEN1; presenilin 1
2932  GSK3B; glycogen synthase kinase 3 beta
3798  KIF5A; kinesin family member 5A
3799  KIF5B; kinesin family member 5B
3800  KIF5C; kinesin family member 5C
3831  KLC1; kinesin light chain 1
64837  KLC2; kinesin light chain 2
147700  KLC3; kinesin light chain 3
89953  KLC4; kinesin light chain 4
Variant
5663v1 (PSEN1*)  PSEN1 mutation
Reference
  Authors
Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J
  Title
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.
  Journal
J Neurosci 23:4499-508 (2003)
DOI:10.1523/JNEUROSCI.23-11-04499.2003
Reference
  Authors
Roy S, Zhang B, Lee VM, Trojanowski JQ
  Title
Axonal transport defects: a common theme in neurodegenerative diseases.
  Journal
Acta Neuropathol 109:5-13 (2005)
DOI:10.1007/s00401-004-0952-x
Reference
  Authors
Dolma K, Iacobucci GJ, Hong Zheng K, Shandilya J, Toska E, White JA 2nd, Spina E, Gunawardena S
  Title
Presenilin influences glycogen synthase kinase-3 beta (GSK-3beta) for kinesin-1 and dynein function during axonal transport.
  Journal
Hum Mol Genet 23:1121-33 (2014)
DOI:10.1093/hmg/ddt505
Reference
  Authors
Wang ZX, Tan L, Yu JT
  Title
Axonal transport defects in Alzheimer's disease.
  Journal
Mol Neurobiol 51:1309-21 (2015)
DOI:10.1007/s12035-014-8810-x
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