KEGG   NETWORK: N01018
Entry
N01018                      Network                                

Name
Mutation-caused aberrant Abeta to anterograde axonal transport
Definition
APP* -> Abeta -> CHRNA7 -> Ca2+ -> CAPN -> CDK5R1 -- CDK5 -> MAPT -| (TUBA+TUBB)
  Expanded
351v1 -> (C16515,C16514) -> 1139 -> C00076 -> (823,824) -> 8851 -- 1020 -> 4137 -| ((7846,10376,84790,7278,113457,112714,7277,51807)+(203068,81027,7280,347733,10381,10382,10383,84617,347688))
Class
nt06419 Microtubule-based transport
nt06460 Alzheimer disease
Type
Variant
Pathway
hsa05010  Alzheimer disease
Disease
H00056  Alzheimer disease
Gene
351  APP; amyloid beta precursor protein
1139  CHRNA7; cholinergic receptor nicotinic alpha 7 subunit
823  CAPN1; calpain 1
824  CAPN2; calpain 2
8851  CDK5R1; cyclin dependent kinase 5 regulatory subunit 1
1020  CDK5; cyclin dependent kinase 5
4137  MAPT; microtubule associated protein tau
7846  TUBA1A; tubulin alpha 1a
10376  TUBA1B; tubulin alpha 1b
84790  TUBA1C; tubulin alpha 1c
7278  TUBA3C; tubulin alpha 3c
113457  TUBA3D; tubulin alpha 3d
112714  TUBA3E; tubulin alpha 3e
7277  TUBA4A; tubulin alpha 4a
51807  TUBA8; tubulin alpha 8
203068  TUBB; tubulin beta class I
81027  TUBB1; tubulin beta 1 class VI
7280  TUBB2A; tubulin beta 2A class IIa
347733  TUBB2B; tubulin beta 2B class IIb
10381  TUBB3; tubulin beta 3 class III
10382  TUBB4A; tubulin beta 4A class IVa
10383  TUBB4B; tubulin beta 4B class IVb
84617  TUBB6; tubulin beta 6 class V
347688  TUBB8; tubulin beta 8 class VIII
Variant
351v1 (APP*)  APP mutation
Metabolite
C16515  Beta-amyloid protein 42
C16514  Beta-amyloid protein 40
C00076  Calcium cation
Reference
  Authors
Wasser CR, Herz J
  Title
Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.
  Journal
J Biol Chem 292:1330-1338 (2017)
DOI:10.1074/jbc.R116.766782
Reference
  Authors
Vargas LM, Cerpa W, Munoz FJ, Zanlungo S, Alvarez AR
  Title
Amyloid-beta oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.
  Journal
Biochim Biophys Acta Mol Basis Dis 1864:1148-1159 (2018)
DOI:10.1016/j.bbadis.2018.01.023
Reference
  Authors
Wang ZX, Tan L, Yu JT
  Title
Axonal transport defects in Alzheimer's disease.
  Journal
Mol Neurobiol 51:1309-21 (2015)
DOI:10.1007/s12035-014-8810-x
Reference
  Authors
Zempel H, Thies E, Mandelkow E, Mandelkow EM
  Title
Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines.
  Journal
J Neurosci 30:11938-50 (2010)
DOI:10.1523/JNEUROSCI.2357-10.2010
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