KEGG   NETWORK: N01020
Entry
N01020                      Network                                

Name
Mutation-inactivated PRKN to Parkin-mediated ubiquitination
Definition
UBCH7/8 // PRKN* // alphaSp22
  Expanded
(7332,9246) // 5071v1 // 6622
Class
nt06420 Ubiquitin-proteasome system
nt06463 Parkinson disease
Type
Variant
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
7332  UBE2L3; ubiquitin conjugating enzyme E2 L3
9246  UBE2L6; ubiquitin conjugating enzyme E2 L6
5071  PRKN; parkin RBR E3 ubiquitin protein ligase
6622  SNCA; synuclein alpha
Variant
5071v1 (PRKN*)  PRKN mutation
Reference
  Authors
Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ.
  Title
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.
  Journal
Science 293:263-9 (2001)
DOI:10.1126/science.1060627
Reference
  Authors
Dev KK, van der Putten H, Sommer B, Rovelli G
  Title
Part I: parkin-associated proteins and Parkinson's disease.
  Journal
Neuropharmacology 45:1-13 (2003)
DOI:10.1016/s0028-3908(02)00337-4
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