KEGG   NETWORK: N01021
Entry
N01021                      Network                                

Name
Parkin-mediated ubiquitination
Definition
UBCH7/8 -- PRKN -| PAELR
  Expanded
(7332,9246) -- 5071 -| 2861
Class
nt06420 Ubiquitin-proteasome system
nt06463 Parkinson disease
Type
Reference
Pathway
hsa04120  Ubiquitin mediated proteolysis
Gene
7332  UBE2L3; ubiquitin conjugating enzyme E2 L3
9246  UBE2L6; ubiquitin conjugating enzyme E2 L6
5071  PRKN; parkin RBR E3 ubiquitin protein ligase
2861  GPR37; G protein-coupled receptor 37
Reference
  Authors
Hattori N, Mizuno Y
  Title
Twenty years since the discovery of the parkin gene.
  Journal
J Neural Transm (Vienna) 124:1037-1054 (2017)
DOI:10.1007/s00702-017-1742-7
Reference
  Authors
Dev KK, van der Putten H, Sommer B, Rovelli G
  Title
Part I: parkin-associated proteins and Parkinson's disease.
  Journal
Neuropharmacology 45:1-13 (2003)
DOI:10.1016/s0028-3908(02)00337-4
Reference
  Authors
Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R
  Title
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.
  Journal
Cell 105:891-902 (2001)
DOI:10.1016/s0092-8674(01)00407-x
Reference
  Authors
Omura T, Kaneko M, Okuma Y, Matsubara K, Nomura Y
  Title
Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease.
  Journal
Oxid Med Cell Longev 2013:239854 (2013)
DOI:10.1155/2013/239854
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