KEGG   NETWORK: N01022
Entry
N01022                      Network                                

Name
Mutation-inactivated PRKN to Parkin-mediated ubiquitination
Definition
UBCH7/8 // PRKN* // PAELR
  Expanded
(7332,9246) // 5071v1 // 2861
Class
nt06420 Ubiquitin-proteasome system
nt06463 Parkinson disease
Type
Variant
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
7332  UBE2L3; ubiquitin conjugating enzyme E2 L3
9246  UBE2L6; ubiquitin conjugating enzyme E2 L6
5071  PRKN; parkin RBR E3 ubiquitin protein ligase
2861  GPR37; G protein-coupled receptor 37
Variant
5071v1 (PRKN*)  PRKN mutation
Reference
  Authors
Imai Y, Soda M, Takahashi R
  Title
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity.
  Journal
J Biol Chem 275:35661-4 (2000)
DOI:10.1074/jbc.C000447200
Reference
  Authors
Dev KK, van der Putten H, Sommer B, Rovelli G
  Title
Part I: parkin-associated proteins and Parkinson's disease.
  Journal
Neuropharmacology 45:1-13 (2003)
DOI:10.1016/s0028-3908(02)00337-4
Reference
  Authors
Omura T, Kaneko M, Okuma Y, Matsubara K, Nomura Y
  Title
Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease.
  Journal
Oxid Med Cell Longev 2013:239854 (2013)
DOI:10.1155/2013/239854
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