KEGG   NETWORK: N01037
Entry
N01037                      Network                                

Name
Mutation-caused aberrant SNCA to L-DOPA generation
Definition
SNCA* // TH -> L-Dopa
  Expanded
6622v1 // 7054 -> C00355
Class
nt06422 Dopamine metabolism
nt06463 Parkinson disease
Type
Variant
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
6622  SNCA; synuclein alpha
7054  TH; tyrosine hydroxylase
Variant
6622v1 (SNCA*)  SNCA mutation
Metabolite
C00355  3,4-Dihydroxy-L-phenylalanine
Reference
  Authors
Perez RG, Waymire JC, Lin E, Liu JJ, Guo F, Zigmond MJ
  Title
A role for alpha-synuclein in the regulation of dopamine biosynthesis.
  Journal
J Neurosci 22:3090-9 (2002)
DOI:10.1523/JNEUROSCI.22-08-03090.2002
Reference
  Authors
Perez RG, Hastings TG
  Title
Could a loss of alpha-synuclein function put dopaminergic neurons at risk?
  Journal
J Neurochem 89:1318-24 (2004)
DOI:10.1111/j.1471-4159.2004.02423.x
Reference
  Authors
Jesko H, Lenkiewicz AM, Wilkaniec A, Adamczyk A
  Title
The interplay between parkin and alpha-synuclein; possible implications for the pathogenesis of Parkinson's disease.
  Journal
Acta Neurobiol Exp (Wars) 79:276-289 (2019)
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