KEGG   NETWORK: N01048
Entry
N01048                      Network                                

Name
Mutation-inactivated PINK1 to intrinsic apoptotic pathway
Definition
PINK1* // (HTRA2,TRAP1) // CYCS -- APAF1 -> CASP9 -> CASP3
  Expanded
65018v1 // (27429,10131) -| 54205 -- 317 -> 842 -> 836
Class
nt06414 Apoptosis
nt06463 Parkinson disease
Type
Variant
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
65018  PINK1; PTEN induced kinase 1
27429  HTRA2; HtrA serine peptidase 2
10131  TRAP1; TNF receptor associated protein 1
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
Variant
65018v1 (PINK1*)  PINK1 mutation
Reference
  Authors
Bueler H
  Title
Mitochondrial dynamics, cell death and the pathogenesis of Parkinson's disease.
  Journal
Apoptosis 15:1336-53 (2010)
DOI:10.1007/s10495-010-0465-0
Reference
  Authors
Pridgeon JW, Olzmann JA, Chin LS, Li L
  Title
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1.
  Journal
PLoS Biol 5:e172 (2007)
DOI:10.1371/journal.pbio.0050172
Reference
  Authors
de Castro IP, Martins LM, Tufi R
  Title
Mitochondrial quality control and neurological disease: an emerging connection.
  Journal
Expert Rev Mol Med 12:e12 (2010)
DOI:10.1017/S1462399410001456
Reference
  Authors
Franco-Iborra S, Vila M, Perier C
  Title
The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?
  Journal
Neuroscientist 22:266-77 (2016)
DOI:10.1177/1073858415574600
Reference
  Authors
Bose A, Beal MF
  Title
Mitochondrial dysfunction in Parkinson's disease.
  Journal
J Neurochem 139 Suppl 1:216-231 (2016)
DOI:10.1111/jnc.13731
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