KEGG   NETWORK: N01049
Entry
N01049                      Network                                

Name
Mutation-inactivated PRKN to intrinsic apoptotic pathway
Definition
PRKN* // BAX -> CYCS -- APAF1 -> CASP9 -> CASP3
  Expanded
5071v1 // 581 -> 54205 -- 317 -> 842 -> 836
Class
nt06414 Apoptosis
nt06463 Parkinson disease
Type
Variant
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
5071  PRKN; parkin RBR E3 ubiquitin protein ligase
581  BAX; BCL2 associated X, apoptosis regulator
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
Variant
5071v1 (PRKN*)  PRKN mutation
Reference
  Authors
Charan RA, Johnson BN, Zaganelli S, Nardozzi JD, LaVoie MJ
  Title
Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin.
  Journal
Cell Death Dis 5:e1313 (2014)
DOI:10.1038/cddis.2014.278
Reference
  Authors
Franco-Iborra S, Vila M, Perier C
  Title
The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?
  Journal
Neuroscientist 22:266-77 (2016)
DOI:10.1177/1073858415574600
Reference
  Authors
Bose A, Beal MF
  Title
Mitochondrial dysfunction in Parkinson's disease.
  Journal
J Neurochem 139 Suppl 1:216-231 (2016)
DOI:10.1111/jnc.13731
Reference
  Authors
Bernardini JP, Brouwer JM, Tan IK, Sandow JJ, Huang S, Stafford CA, Bankovacki A, Riffkin CD, Wardak AZ, Czabotar PE, Lazarou M, Dewson G
  Title
Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy.
  Journal
EMBO J 38:e99916 (2019)
DOI:10.15252/embj.201899916
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