KEGG   NETWORK: N01054
Entry
N01054                      Network                                

Name
Mutation-inactivated PRKN to PINK1-Parkin-mediated MFN2 degradation
Definition
PRKN* // MFN1/2
  Expanded
5071v1 // (55669,9927)
Class
nt06421 Mitophagy
nt06463 Parkinson disease
Type
Variant
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
5071  PRKN; parkin RBR E3 ubiquitin protein ligase
55669  MFN1; mitofusin 1
9927  MFN2; mitofusin 2
Variant
5071v1  PRKN mutation
Reference
  Authors
Rakovic A, Grunewald A, Kottwitz J, Bruggemann N, Pramstaller PP, Lohmann K, Klein C
  Title
Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts.
  Journal
PLoS One 6:e16746 (2011)
DOI:10.1371/journal.pone.0016746
Reference
  Authors
Devine MJ, Plun-Favreau H, Wood NW
  Title
Parkinson's disease and cancer: two wars, one front.
  Journal
Nat Rev Cancer 11:812-23 (2011)
DOI:10.1038/nrc3150
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