KEGG   NETWORK: N01055
Entry
N01055                      Network                                

Name
Mutation-caused aberrant SNCA to anterograde axonal transport
Definition
SNCA* -| (KIF5+KLC) // (TUBA+TUBB)
  Expanded
6622v1 -| ((3798,3799,3800)+(3831,64837,147700,89953)) // ((7846,10376,84790,7278,113457,112714,7277,51807)+(203068,81027,7280,347733,10381,10382,10383,84617,347688))
Class
nt06419 Microtubule-based transport
nt06463 Parkinson disease
Type
Variant
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
6622  SNCA; synuclein alpha
3798  KIF5A; kinesin family member 5A
3799  KIF5B; kinesin family member 5B
3800  KIF5C; kinesin family member 5C
3831  KLC1; kinesin light chain 1
64837  KLC2; kinesin light chain 2
147700  KLC3; kinesin light chain 3
89953  KLC4; kinesin light chain 4
7846  TUBA1A; tubulin alpha 1a
10376  TUBA1B; tubulin alpha 1b
84790  TUBA1C; tubulin alpha 1c
7278  TUBA3C; tubulin alpha 3c
113457  TUBA3D; tubulin alpha 3d
112714  TUBA3E; tubulin alpha 3e
7277  TUBA4A; tubulin alpha 4a
51807  TUBA8; tubulin alpha 8
203068  TUBB; tubulin beta class I
81027  TUBB1; tubulin beta 1 class VI
7280  TUBB2A; tubulin beta 2A class IIa
347733  TUBB2B; tubulin beta 2B class IIb
10381  TUBB3; tubulin beta 3 class III
10382  TUBB4A; tubulin beta 4A class IVa
10383  TUBB4B; tubulin beta 4B class IVb
84617  TUBB6; tubulin beta 6 class V
347688  TUBB8; tubulin beta 8 class VIII
Variant
6622v1 (SNCA*)  SNCA mutation
Reference
  Authors
Melo TQ, Copray SJCVM, Ferrari MFR
  Title
Alpha-Synuclein Toxicity on Protein Quality Control, Mitochondria and Endoplasmic Reticulum.
  Journal
Neurochem Res 43:2212-2223 (2018)
DOI:10.1007/s11064-018-2673-x
Reference
  Authors
Valdinocci D, Simoes RF, Kovarova J, Cunha-Oliveira T, Neuzil J, Pountney DL
  Title
Intracellular and Intercellular Mitochondrial Dynamics in Parkinson's Disease.
  Journal
Front Neurosci 13:930 (2019)
DOI:10.3389/fnins.2019.00930
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