KEGG   NETWORK: N01056
Entry
N01056                      Network                                

Name
FAS-JNK signaling pathway
Definition
FASLG -> FAS -> (DAXX+ASK1) -> JNK
  Expanded
356 -> 355 -> (1616+4217) -> (5599,5601,5602)
Class
nt06414 Apoptosis
nt06463 Parkinson disease
Type
Reference
Pathway
hsa04210  Apoptosis
Gene
356  FASLG; Fas ligand
355  FAS; Fas cell surface death receptor
1616  DAXX; death domain associated protein
4217  MAP3K5; mitogen-activated protein kinase kinase kinase 5
5599  MAPK8; mitogen-activated protein kinase 8
5601  MAPK9; mitogen-activated protein kinase 9
5602  MAPK10; mitogen-activated protein kinase 10
Reference
PMID:9743501
  Authors
Chang HY, Nishitoh H, Yang X, Ichijo H, Baltimore D
  Title
Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.
  Journal
Science 281:1860-3 (1998)
DOI:10.1126/science.281.5384.1860
Reference
PMID:9215629
  Authors
Yang X, Khosravi-Far R, Chang HY, Baltimore D
  Title
Daxx, a novel Fas-binding protein that activates JNK and apoptosis.
  Journal
Cell 89:1067-76 (1997)
DOI:10.1016/S0092-8674(00)80294-9
Reference
  Authors
Leist M, Jaattela M
  Title
Four deaths and a funeral: from caspases to alternative mechanisms.
  Journal
Nat Rev Mol Cell Biol 2:589-98 (2001)
DOI:10.1038/35085008
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