KEGG   NETWORK: N01063
Entry
N01063                      Network                                

Name
Mutation-activated MET to PI3K signaling pathway
Definition
MET* -> GAB1 -> PI3K -> PIP3 -> AKT -> MTOR
  Expanded
4233v4 -> 2549 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475
Class
nt06214 PI3K signaling
nt06266 Non-small cell lung cancer
Type
Variant
Pathway
hsa05223  Non-small cell lung cancer
Disease
H00014  Non-small cell lung cancer
Gene
4233  MET; MET proto-oncogene, receptor tyrosine kinase
2549  GAB1; GRB2 associated binding protein 1
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin kinase
Variant
4233v4 (MET*)  MET exon 14 skipping
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Sundar R, Chenard-Poirier M, Collins DC, Yap TA
  Title
Imprecision in the Era of Precision Medicine in Non-Small Cell Lung Cancer.
  Journal
Front Med (Lausanne) 4:39 (2017)
DOI:10.3389/fmed.2017.00039
Reference
  Authors
Frampton GM, Ali SM, Rosenzweig M, Chmielecki J, Lu X, Bauer TM, Akimov M, Bufill JA, Lee C, Jentz D, Hoover R, Ou SH, Salgia R, Brennan T, Chalmers ZR, Jaeger S, Huang A, Elvin JA, Erlich R, Fichtenholtz A, Gowen KA, Greenbowe J, Johnson A, Khaira D, McMahon C, Sanford EM, Roels S, White J, Greshock J, Schlegel R, Lipson D, Yelensky R, Morosini D, Ross JS, Collisson E, Peters M, Stephens PJ, Miller VA
  Title
Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors.
  Journal
Cancer Discov 5:850-9 (2015)
DOI:10.1158/2159-8290.CD-15-0285
Reference
  Authors
Lee GD, Lee SE, Oh DY, Yu DB, Jeong HM, Kim J, Hong S, Jung HS, Oh E, Song JY, Lee MS, Kim M, Jung K, Kim J, Shin YK, Choi YL, Kim HR
  Title
MET Exon 14 Skipping Mutations in Lung Adenocarcinoma: Clinicopathologic Implications and Prognostic Values.
  Journal
J Thorac Oncol 12:1233-1246 (2017)
DOI:10.1016/j.jtho.2017.04.031
Reference
  Authors
Drilon A, Cappuzzo F, Ou SI, Camidge DR
  Title
Targeting MET in Lung Cancer: Will Expectations Finally Be MET?
  Journal
J Thorac Oncol 12:15-26 (2017)
DOI:10.1016/j.jtho.2016.10.014
Reference
  Authors
Organ SL, Tsao MS
  Title
An overview of the c-MET signaling pathway.
  Journal
Ther Adv Med Oncol 3:S7-S19 (2011)
DOI:10.1177/1758834011422556
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