KEGG   NETWORK: N01068
Entry
N01068                      Network                                

Name
ITGA/B-FAK-RAC signaling pathway
Definition
FN1 -> (ITGA+ITGB) -> (SRC,PTK2) -> (PXN,CRK+BCAR1) -> (DOCK1+ELMO1) -> RAC
  Expanded
2335 -> ((3672,3673,3674,3675,3676,3678,3679,8516,3680,8515,22801,3685)+(3688,3690,3691,3693,3694,3695,3696)) -> (6714,5747) -> (5829,(1398+9564)) -> (1793+9844) -> (5879,5880,5881)
Class
nt06135 Cytoskeletal regulation (viruses)
Type
Reference
Pathway
hsa04810  Regulation of actin cytoskeleton
hsa04510  Focal adhesion
Gene
2335  FN1; fibronectin 1
3672  ITGA1; integrin subunit alpha 1
3673  ITGA2; integrin subunit alpha 2
3674  ITGA2B; integrin subunit alpha 2b
3675  ITGA3; integrin subunit alpha 3
3676  ITGA4; integrin subunit alpha 4
3678  ITGA5; integrin subunit alpha 5
3679  ITGA7; integrin subunit alpha 7
8516  ITGA8; integrin subunit alpha 8
3680  ITGA9; integrin subunit alpha 9
8515  ITGA10; integrin subunit alpha 10
22801  ITGA11; integrin subunit alpha 11
3685  ITGAV; integrin subunit alpha V
3688  ITGB1; integrin subunit beta 1
3690  ITGB3; integrin subunit beta 3
3691  ITGB4; integrin subunit beta 4
3693  ITGB5; integrin subunit beta 5
3694  ITGB6; integrin subunit beta 6
3695  ITGB7; integrin subunit beta 7
3696  ITGB8; integrin subunit beta 8
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
5747  PTK2; protein tyrosine kinase 2
5829  PXN; paxillin
1398  CRK; CRK proto-oncogene, adaptor protein
9564  BCAR1; BCAR1 scaffold protein, Cas family member
1793  DOCK1; dedicator of cytokinesis 1
9844  ELMO1; engulfment and cell motility 1
5879  RAC1; Rac family small GTPase 1
5880  RAC2; Rac family small GTPase 2
5881  RAC3; Rac family small GTPase 3
Reference
  Authors
Guan X, Guan X, Dong C, Jiao Z
  Title
Rho GTPases and related signaling complexes in cell migration and invasion.
  Journal
Exp Cell Res 388:111824 (2020)
DOI:10.1016/j.yexcr.2020.111824
Reference
  Authors
Lawson CD, Burridge K
  Title
The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration.
  Journal
Small GTPases 5:e27958 (2014)
DOI:10.4161/sgtp.27958
Reference
  Authors
Huveneers S, Danen EH
  Title
Adhesion signaling - crosstalk between integrins, Src and Rho.
  Journal
J Cell Sci 122:1059-69 (2009)
DOI:10.1242/jcs.039446
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