KEGG   NETWORK: N01070
Entry
N01070                      Network                                

Name
ITGA/B-FAK-CDC42 signaling pathway
Definition
FN1 -> (ITGA+ITGB) -> (SRC,PTK2) -> PXN -> (GIT2+ARHGEF7) -> CDC42
  Expanded
2335 -> ((3672,3673,3674,3675,3676,3678,3679,8516,3680,8515,22801,3685)+(3688,3690,3691,3693,3694,3695,3696)) -> (6714,5747) -> 5829 -> (9815+8874) -> 998
Class
nt06135 Cytoskeletal regulation (viruses and bacteria)
Type
Reference
Gene
2335  FN1; fibronectin 1
3672  ITGA1; integrin subunit alpha 1
3673  ITGA2; integrin subunit alpha 2
3674  ITGA2B; integrin subunit alpha 2b
3675  ITGA3; integrin subunit alpha 3
3676  ITGA4; integrin subunit alpha 4
3678  ITGA5; integrin subunit alpha 5
3679  ITGA7; integrin subunit alpha 7
8516  ITGA8; integrin subunit alpha 8
3680  ITGA9; integrin subunit alpha 9
8515  ITGA10; integrin subunit alpha 10
22801  ITGA11; integrin subunit alpha 11
3685  ITGAV; integrin subunit alpha V
3688  ITGB1; integrin subunit beta 1
3690  ITGB3; integrin subunit beta 3
3691  ITGB4; integrin subunit beta 4
3693  ITGB5; integrin subunit beta 5
3694  ITGB6; integrin subunit beta 6
3695  ITGB7; integrin subunit beta 7
3696  ITGB8; integrin subunit beta 8
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
5747  PTK2; protein tyrosine kinase 2
5829  PXN; paxillin
9815  GIT2; GIT ArfGAP 2
8874  ARHGEF7; Rho guanine nucleotide exchange factor 7
998  CDC42; cell division cycle 42
Reference
  Authors
Huveneers S, Danen EH
  Title
Adhesion signaling - crosstalk between integrins, Src and Rho.
  Journal
J Cell Sci 122:1059-69 (2009)
DOI:10.1242/jcs.039446
Reference
  Authors
Yu JA, Deakin NO, Turner CE
  Title
Emerging role of paxillin-PKL in regulation of cell adhesion, polarity and migration.
  Journal
Cell Adh Migr 4:342-7 (2010)
DOI:10.4161/cam.4.3.11406
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