KEGG   NETWORK: N01078
Entry
N01078                      Network                                

Name
EGF-EGFR-Actin signaling pathway
Definition
EGF -> EGFR -> SRC -> CTTN -> NCK -> (WASL+WIPF) -> ARP2/3 -> (ACTB,ACTG1)
  Expanded
1950 -> 1956 -> 6714 -> 2017 -> (4690,8440) -> (8976+(7456,147179,644150)) -> (10097+10096+10552+10095+10109+10094+10093+10092+81873) -> (60,71)
Class
nt06135 Cytoskeletal regulation (viruses)
Type
Reference
Gene
1950  EGF; epidermal growth factor
1956  EGFR; epidermal growth factor receptor
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
2017  CTTN; cortactin
4690  NCK1; NCK adaptor protein 1
8440  NCK2; NCK adaptor protein 2
8976  WASL; WASP like actin nucleation promoting factor
7456  WIPF1; WAS/WASL interacting protein family member 1
147179  WIPF2; WAS/WASL interacting protein family member 2
644150  WIPF3; WAS/WASL interacting protein family member 3
10097  ACTR2; actin related protein 2
10096  ACTR3; actin related protein 3
10552  ARPC1A; actin related protein 2/3 complex subunit 1A
10095  ARPC1B; actin related protein 2/3 complex subunit 1B
10109  ARPC2; actin related protein 2/3 complex subunit 2
10094  ARPC3; actin related protein 2/3 complex subunit 3
10093  ARPC4; actin related protein 2/3 complex subunit 4
10092  ARPC5; actin related protein 2/3 complex subunit 5
81873  ARPC5L; actin related protein 2/3 complex subunit 5 like
60  ACTB; actin beta
71  ACTG1; actin gamma 1
Reference
  Authors
Reynolds AB, Kanner SB, Bouton AH, Schaller MD, Weed SA, Flynn DC, Parsons JT
  Title
SRChing for the substrates of Src.
  Journal
Oncogene 33:4537-47 (2014)
DOI:10.1038/onc.2013.416
Reference
  Authors
Tehrani S, Tomasevic N, Weed S, Sakowicz R, Cooper JA
  Title
Src phosphorylation of cortactin enhances actin assembly.
  Journal
Proc Natl Acad Sci U S A 104:11933-8 (2007)
DOI:10.1073/pnas.0701077104
Reference
  Authors
Oser M, Mader CC, Gil-Henn H, Magalhaes M, Bravo-Cordero JJ, Koleske AJ, Condeelis J
  Title
Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia.
  Journal
J Cell Sci 123:3662-73 (2010)
DOI:10.1242/jcs.068163
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