KEGG   NETWORK: N01081
Entry
N01081                      Network                                

Name
Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway
Definition
(IpaB+IpaC,IpaD) -> (ITGA5+ITGB1) -> (PTK2+PXN) -> (TLN+VCN) -> (ACTB,ACTG1)
  Expanded
((K13285+K13286),K13287) -> (3678+3688) -> (5747+5829) -> ((7094,83660)+7414) -> (60,71)
Class
nt06135 Cytoskeletal regulation (viruses and bacteria)
Type
Pathogen
Pathway
hsa05131  Shigellosis
Disease
H00299  Shigellosis
Gene
3678  ITGA5; integrin subunit alpha 5
3688  ITGB1; integrin subunit beta 1
5747  PTK2; protein tyrosine kinase 2
5829  PXN; paxillin
7094  TLN1; talin 1
83660  TLN2; talin 2
7414  VCL; vinculin
60  ACTB; actin beta
71  ACTG1; actin gamma 1
Perturbant
K13285 (IpaB)  sipB; invasin B
K13286 (IpaC)  sipC; invasin C
K13287 (IpaD)  sipD; invasin D
Reference
PMID:9016877
  Authors
Watarai M, Kamata Y, Kozaki S, Sasakawa C
  Title
rho, a small GTP-binding protein, is essential for Shigella invasion of epithelial cells.
  Journal
J Exp Med 185:281-92 (1997)
DOI:10.1084/jem.185.2.281
Reference
PMID:8642302
  Authors
Watarai M, Funato S, Sasakawa C
  Title
Interaction of Ipa proteins of Shigella flexneri with alpha5beta1 integrin promotes entry of the bacteria into mammalian cells.
  Journal
J Exp Med 183:991-9 (1996)
DOI:10.1084/jem.183.3.991
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