KEGG   NETWORK: N01097
Entry
N01097                      Network                                

Name
LPA-GNA12/13-RhoA signaling pathway
Definition
LPA -> LPAR -> GNA12/13 -> (ARHGEF12,ARHGEF1,ARHGEF11) -> RHOA -> ROCK1/2
  Expanded
C00681 -> (1902,9170,23566,2846,57121) -> (2768,10672) -> (23365,9138,9826) -> 387 -> (6093,9475)
Class
nt06135 Cytoskeletal regulation (viruses)
Type
Reference
Pathway
hsa04810  Regulation of actin cytoskeleton
Gene
1902  LPAR1; lysophosphatidic acid receptor 1
9170  LPAR2; lysophosphatidic acid receptor 2
23566  LPAR3; lysophosphatidic acid receptor 3
2846  LPAR4; lysophosphatidic acid receptor 4
57121  LPAR5; lysophosphatidic acid receptor 5
2768  GNA12; G protein subunit alpha 12
10672  GNA13; G protein subunit alpha 13
23365  ARHGEF12; Rho guanine nucleotide exchange factor 12
9138  ARHGEF1; Rho guanine nucleotide exchange factor 1
9826  ARHGEF11; Rho guanine nucleotide exchange factor 11
387  RHOA; ras homolog family member A
6093  ROCK1; Rho associated coiled-coil containing protein kinase 1
9475  ROCK2; Rho associated coiled-coil containing protein kinase 2
Metabolite
C00681  1-Acyl-sn-glycerol 3-phosphate
Reference
  Authors
Kozasa T, Hajicek N, Chow CR, Suzuki N
  Title
Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13.
  Journal
J Biochem 150:357-69 (2011)
DOI:10.1093/jb/mvr105
Reference
  Authors
O'Connor K, Chen M
  Title
Dynamic functions of RhoA in tumor cell migration and invasion.
  Journal
Small GTPases 4:141-7 (2013)
DOI:10.4161/sgtp.25131
Reference
  Authors
Riaz A, Huang Y, Johansson S
  Title
G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling.
  Journal
Int J Mol Sci 17:215 (2016)
DOI:10.3390/ijms17020215
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