Entry |
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Name |
TCR-PLCG-ITPR signaling pathway
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Definition |
(TCR+CD3+CD4) -> (LCK,FYN,ZAP70) -> (SLP76+GADS+LAT+VAV) -> PLCG -> IP3 -> ITPR -> Ca2+(cyto) |
Expanded |
((915+916+917+919)+920) -> (3932,2534,7535) -> (3937+9402+27040+(7409,7410,10451)) -> (5335,5336) -> C01245 -> (3708,3709,3710) -> C00076 |
Class |
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Type |
Reference
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Pathway |
hsa04660 | T cell receptor signaling pathway |
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Gene |
915 | CD3D; CD3 delta subunit of T-cell receptor complex |
916 | CD3E; CD3 epsilon subunit of T-cell receptor complex |
917 | CD3G; CD3 gamma subunit of T-cell receptor complex |
919 | CD247; CD247 molecule |
3932 | LCK; LCK proto-oncogene, Src family tyrosine kinase |
2534 | FYN; FYN proto-oncogene, Src family tyrosine kinase |
7535 | ZAP70; zeta chain of T cell receptor associated protein kinase 70 |
3937 | LCP2; lymphocyte cytosolic protein 2 |
9402 | GRAP2; GRB2 related adaptor protein 2 |
27040 | LAT; linker for activation of T cells |
7409 | VAV1; vav guanine nucleotide exchange factor 1 |
7410 | VAV2; vav guanine nucleotide exchange factor 2 |
10451 | VAV3; vav guanine nucleotide exchange factor 3 |
5335 | PLCG1; phospholipase C gamma 1 |
5336 | PLCG2; phospholipase C gamma 2 |
3708 | ITPR1; inositol 1,4,5-trisphosphate receptor type 1 |
3709 | ITPR2; inositol 1,4,5-trisphosphate receptor type 2 |
3710 | ITPR3; inositol 1,4,5-trisphosphate receptor type 3 |
|
Metabolite |
C01245 | D-myo-Inositol 1,4,5-trisphosphate |
|
Reference |
|
Authors |
Gaud G, Lesourne R, Love PE |
Title |
Regulatory mechanisms in T cell receptor signalling. |
Journal |
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Reference |
|
Authors |
Brownlie RJ, Zamoyska R |
Title |
T cell receptor signalling networks: branched, diversified and bounded. |
Journal |
|
Reference |
|
Authors |
Trebak M, Kinet JP |
Title |
Calcium signalling in T cells. |
Journal |
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LinkDB |
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