KEGG   NETWORK: N01112
Entry
N01112                      Network                                

Name
Salmonella SopE/E2 to NOD-NFKB signaling pathway
Definition
SopE/E2 -> CDC42 -> NOD1 -> RIPK2 -> IKK -> NFKBIA -> NFKB
  Expanded
K13741 -> 998 -> 10392 -> 8767 -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06139 NLR signaling (viruses and bacteria)
Type
Pathogen
Pathway
hsa05132  Salmonella infection
Disease
H00113  Salmonellosis
Gene
998  CDC42; cell division cycle 42
10392  NOD1; nucleotide binding oligomerization domain containing 1
8767  RIPK2; receptor interacting serine/threonine kinase 2
1147  CHUK; component of inhibitor of nuclear factor kappa B kinase complex
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Perturbant
K13741 (SopE/E2)  sopE; guanine nucleotide exchange factor SopE
Reference
  Authors
Keestra AM, Winter MG, Auburger JJ, Frassle SP, Xavier MN, Winter SE, Kim A, Poon V, Ravesloot MM, Waldenmaier JF, Tsolis RM, Eigenheer RA, Baumler AJ
  Title
Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1.
  Journal
Nature 496:233-7 (2013)
DOI:10.1038/nature12025
Reference
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
LinkDB

DBGET integrated database retrieval system