KEGG   NETWORK: N01126
Entry
N01126                      Network                                

Name
Salmonella SipB to Inflammasome signaling pathway
Definition
SipB -> CASP1 -> (IL1B,IL18)
  Expanded
K13285 -> 834 -> (3553,3606)
Class
nt06139 NLR signaling (viruses and bacteria)
Type
Pathogen
Pathway
hsa05132  Salmonella infection
Disease
H00113  Salmonellosis
Gene
834  CASP1; caspase 1
3553  IL1B; interleukin 1 beta
3606  IL18; interleukin 18
Perturbant
K13285 (SipB)  sipB; invasin B
Reference
  Authors
Hersh D, Monack DM, Smith MR, Ghori N, Falkow S, Zychlinsky A
  Title
The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1.
  Journal
Proc Natl Acad Sci U S A 96:2396-401 (1999)
DOI:10.1073/pnas.96.5.2396
Reference
  Authors
Dreher D, Kok M, Obregon C, Kiama SG, Gehr P, Nicod LP
  Title
Salmonella virulence factor SipB induces activation and release of IL-18 in human dendritic cells.
  Journal
J Leukoc Biol 72:743-51 (2002)
DOI:10.1189/jlb.72.4.743
Reference
  Authors
van der Velden AW, Velasquez M, Starnbach MN
  Title
Salmonella rapidly kill dendritic cells via a caspase-1-dependent mechanism.
  Journal
J Immunol 171:6742-9 (2003)
DOI:10.4049/jimmunol.171.12.6742
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