KEGG   NETWORK: N01127
Entry
N01127                      Network                                

Name
Salmonella SopE to Inflammasome signaling pathway
Definition
SopE -> RAC1 -> CASP1 -> (IL1B,IL18)
  Expanded
K13741 -> 5879 -> 834 -> (3553,3606)
Class
nt06139 NLR signaling (viruses and bacteria)
Type
Pathogen
Pathway
hsa05132  Salmonella infection
Disease
H00113  Salmonellosis
Gene
5879  RAC1; Rac family small GTPase 1
834  CASP1; caspase 1
3553  IL1B; interleukin 1 beta
3606  IL18; interleukin 18
Perturbant
K13741 (SopE)  sopE; guanine nucleotide exchange factor SopE
Reference
  Authors
Muller AJ, Hoffmann C, Galle M, Van Den Broeke A, Heikenwalder M, Falter L, Misselwitz B, Kremer M, Beyaert R, Hardt WD
  Title
The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation.
  Journal
Cell Host Microbe 6:125-36 (2009)
DOI:10.1016/j.chom.2009.07.007
Reference
  Authors
Hoffmann C, Galle M, Dilling S, Kappeli R, Muller AJ, Songhet P, Beyaert R, Hardt WD
  Title
In macrophages, caspase-1 activation by SopE and the type III secretion system-1 of S. typhimurium can proceed in the absence of flagellin.
  Journal
PLoS One 5:e12477 (2010)
DOI:10.1371/journal.pone.0012477
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