KEGG   NETWORK: N01163
Entry
N01163                      Network                                

Name
NRG-ERBB4-PI3K signaling pathway
Definition
NRG -> ERBB4 -> PI3K -> PIP3 -> AKT
  Expanded
(3084,9542,10718,145957) -> 2066 -> (5290,5291,5293) -> C05981 -> (207,208,10000)
Class
nt06415 PI3K signaling
nt06464 Amyotrophic lateral sclerosis
Type
Reference
Pathway
hsa04012  ErbB signaling pathway
Gene
3084  NRG1; neuregulin 1
9542  NRG2; neuregulin 2
10718  NRG3; neuregulin 3
145957  NRG4; neuregulin 4
2066  ERBB4; erb-b2 receptor tyrosine kinase 4
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Mei L, Nave KA
  Title
Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases.
  Journal
Neuron 83:27-49 (2014)
DOI:10.1016/j.neuron.2014.06.007
Reference
  Authors
Liang X, Ding Y, Zhang Y, Chai YH, He J, Chiu SM, Gao F, Tse HF, Lian Q
  Title
Activation of NRG1-ERBB4 signaling potentiates mesenchymal stem cell-mediated myocardial repairs following myocardial infarction.
  Journal
Cell Death Dis 6:e1765 (2015)
DOI:10.1038/cddis.2015.91
Reference
  Authors
Xie F, Padival M, Siegel RE
  Title
Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture.
  Journal
J Neurochem 100:62-72 (2007)
DOI:10.1111/j.1471-4159.2006.04182.x
Reference
  Authors
Vasti C, Hertig CM
  Title
Neuregulin-1/erbB activities with focus on the susceptibility of the heart to anthracyclines.
  Journal
World J Cardiol 6:653-62 (2014)
DOI:10.4330/wjc.v6.i7.653
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