KEGG   NETWORK: N01204
Entry
N01204                      Network                                

Name
PRNP-PI3K-NOX2 signaling pathway
Definition
PRNP -> CAV -> FYN -> PI3K -> PRKCD -> NOX2 -> ERK -> CREB => EGR1
  Expanded
5621 -> (857,858,859) -> 2534 -> (5290,5291,5293) -> 5580 -> ((1536+1535+4689+653361+4688+(5879,5880)) -> (5594,5595) -> (10488,1385,1386,1388,148327,468,64764,84699,90993,9586) => 1958
Class
nt06415 PI3K signaling
nt06465 Prion disease
Type
Reference
Gene
5621  PRNP; prion protein
857  CAV1; caveolin 1
858  CAV2; caveolin 2
859  CAV3; caveolin 3
2534  FYN; FYN proto-oncogene, Src family tyrosine kinase
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5580  PRKCD; protein kinase C delta
1536  CYBB; cytochrome b-245 beta chain
1535  CYBA; cytochrome b-245 alpha chain
4689  NCF4; neutrophil cytosolic factor 4
653361  NCF1; neutrophil cytosolic factor 1
4688  NCF2; neutrophil cytosolic factor 2
5879  RAC1; Rac family small GTPase 1
5880  RAC2; Rac family small GTPase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
10488  CREB3; cAMP responsive element binding protein 3
1385  CREB1; cAMP responsive element binding protein 1
1386  ATF2; activating transcription factor 2
1388  ATF6B; activating transcription factor 6 beta
148327  CREB3L4; cAMP responsive element binding protein 3 like 4
468  ATF4; activating transcription factor 4
64764  CREB3L2; cAMP responsive element binding protein 3 like 2
84699  CREB3L3; cAMP responsive element binding protein 3 like 3
90993  CREB3L1; cAMP responsive element binding protein 3 like 1
9586  CREB5; cAMP responsive element binding protein 5
1958  EGR1; early growth response 1
Reference
  Authors
Mouillet-Richard S, Schneider B, Pradines E, Pietri M, Ermonval M, Grassi J, Richards JG, Mutel V, Launay JM, Kellermann O
  Title
Cellular prion protein signaling in serotonergic neuronal cells.
  Journal
Ann N Y Acad Sci 1096:106-19 (2007)
DOI:10.1196/annals.1397.076
Reference
  Authors
Schneider B, Mutel V, Pietri M, Ermonval M, Mouillet-Richard S, Kellermann O
  Title
NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells.
  Journal
Proc Natl Acad Sci U S A 100:13326-31 (2003)
DOI:10.1073/pnas.2235648100
Reference
  Authors
Schneider B, Pietri M, Pradines E, Loubet D, Launay JM, Kellermann O, Mouillet-Richard S
  Title
Understanding the neurospecificity of Prion protein signaling.
  Journal
Front Biosci (Landmark Ed) 16:169-86 (2011)
DOI:10.2741/3682
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