KEGG   NETWORK: N01295
Entry
N01295                      Network                                

Name
Rab7-regulated microtubule minus-end directed transport
Definition
RAB7 -- RILP -- OSBPL1A -- (DYNC+DYNL+DCTN+ACTR1+ACTR10) -- (TUBA+TUBB)
  Expanded
(7879,338382) -- 83547 -- 114876 -- ((1778+79659+1780+1781+51143+1783+51626+8655+140735+83658+83657+6993+6990)+(1639+10540+11258+51164+84516+10671+10121+10120+55860)) -- ((7846,10376,84790,7278,113457,112714,7277,51807)+(203068,81027,7280,347733,10381,10382,10383,84617,347688))
Class
nt06125 Membrane trafficking (bacteria)
Type
Reference
Pathway
hsa04145 Phagosome   
Gene
7879  RAB7A; RAB7A, member RAS oncogene family
338382  RAB7B; RAB7B, member RAS oncogene family
83547  RILP; Rab interacting lysosomal protein
114876  OSBPL1A; oxysterol binding protein like 1A
1778  DYNC1H1; dynein cytoplasmic 1 heavy chain 1
79659  DYNC2H1; dynein cytoplasmic 2 heavy chain 1
1780  DYNC1I1; dynein cytoplasmic 1 intermediate chain 1
1781  DYNC1I2; dynein cytoplasmic 1 intermediate chain 2
51143  DYNC1LI1; dynein cytoplasmic 1 light intermediate chain 1
1783  DYNC1LI2; dynein cytoplasmic 1 light intermediate chain 2
51626  DYNC2LI1; dynein cytoplasmic 2 light intermediate chain 1
8655  DYNLL1; dynein light chain LC8-type 1
140735  DYNLL2; dynein light chain LC8-type 2
83658  DYNLRB1; dynein light chain roadblock-type 1
83657  DYNLRB2; dynein light chain roadblock-type 2
6993  DYNLT1; dynein light chain Tctex-type 1
6990  DYNLT3; dynein light chain Tctex-type 3
1639  DCTN1; dynactin subunit 1
10540  DCTN2; dynactin subunit 2
11258  DCTN3; dynactin subunit 3
51164  DCTN4; dynactin subunit 4
84516  DCTN5; dynactin subunit 5
10671  DCTN6; dynactin subunit 6
10121  ACTR1A; actin related protein 1A
10120  ACTR1B; actin related protein 1B
55860  ACTR10; actin related protein 10
7846  TUBA1A; tubulin alpha 1a
10376  TUBA1B; tubulin alpha 1b
84790  TUBA1C; tubulin alpha 1c
7278  TUBA3C; tubulin alpha 3c
113457  TUBA3D; tubulin alpha 3d
112714  TUBA3E; tubulin alpha 3e
7277  TUBA4A; tubulin alpha 4a
51807  TUBA8; tubulin alpha 8
203068  TUBB; tubulin beta class I
81027  TUBB1; tubulin beta 1 class VI
7280  TUBB2A; tubulin beta 2A class IIa
347733  TUBB2B; tubulin beta 2B class IIb
10381  TUBB3; tubulin beta 3 class III
10382  TUBB4A; tubulin beta 4A class IVa
10383  TUBB4B; tubulin beta 4B class IVb
84617  TUBB6; tubulin beta 6 class V
347688  TUBB8; tubulin beta 8 class VIII
Reference
  Authors
Pu J, Guardia CM, Keren-Kaplan T, Bonifacino JS
  Title
Mechanisms and functions of lysosome positioning.
  Journal
J Cell Sci 129:4329-4339 (2016)
DOI:10.1242/jcs.196287
Reference
  Authors
Wang T, Ming Z, Xiaochun W, Hong W
  Title
Rab7: role of its protein interaction cascades in endo-lysosomal traffic.
  Journal
Cell Signal 23:516-21 (2011)
DOI:10.1016/j.cellsig.2010.09.012
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