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Entry
N10001                      Network                                

Name
First-generation tyrosine kinase inhibitor to BCR-ABL fusion
Definition
Imatinib -| BCR-ABL1
  Expanded
D01441 -| 25v1
Class
nt06210 ERK signaling
nt06276 Chronic myeloid leukemia
nt06214 PI3K signaling
nt06219 JAK-STAT signaling
Type
Drug target
Gene
25  ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase
Variant
25v1  BCR-ABL1 fusion
Perturbant
D01441  Imatinib mesylate
Reference
PMID:8616716
  Authors
Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, Fanning S, Zimmermann J, Lydon NB
  Title
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells.
  Journal
Nat Med 2:561-6 (1996)
DOI:10.1038/nm0596-561
Reference
PMID:9389713
  Authors
Carroll M, Ohno-Jones S, Tamura S, Buchdunger E, Zimmermann J, Lydon NB, Gilliland DG, Druker BJ
  Title
CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins.
  Journal
Blood 90:4947-52 (1997)
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