| Entry |
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| Name |
Tyrosine kinase inhibitor to HER2 overexpression/amplification
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| Definition |
(Trastuzumab,Trastuzumab_emtansine,Pertuzumab,Lapatinib,Neratinib) -| (ERBB2*,ERBB2*) |
|---|
| Expanded |
(D03257,D09980,D05446,D04024,D10898) -| (2064v1,2064v3) |
|---|
| Class |
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|---|
| Type |
Drug target
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|---|
| Gene |
| 2064 | ERBB2; erb-b2 receptor tyrosine kinase 2 |
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| Variant |
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| Perturbant |
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| Reference |
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| Authors |
Nahta R, Hung MC, Esteva FJ |
|---|
| Title |
The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. |
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| Journal |
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| Reference |
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| Authors |
LoRusso PM, Weiss D, Guardino E, Girish S, Sliwkowski MX |
|---|
| Title |
Trastuzumab emtansine: a unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer. |
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| Journal |
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| LinkDB |
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