KEGG T03372: 103725586

KEGG Orthology (KO) [BR:ngi00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    103725586 (Rps6kb2)
   04350 TGF-beta signaling pathway
    103725586 (Rps6kb2)
   04371 Apelin signaling pathway
    103725586 (Rps6kb2)
   04066 HIF-1 signaling pathway
    103725586 (Rps6kb2)
   04151 PI3K-Akt signaling pathway
    103725586 (Rps6kb2)
   04152 AMPK signaling pathway
    103725586 (Rps6kb2)
   04150 mTOR signaling pathway
    103725586 (Rps6kb2)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103725586 (Rps6kb2)
09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    103725586 (Rps6kb2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103725586 (Rps6kb2)
  09149 Aging
   04211 Longevity regulating pathway
    103725586 (Rps6kb2)
   04213 Longevity regulating pathway - multiple species
    103725586 (Rps6kb2)
  09159 Environmental adaptation
   04714 Thermogenesis
    103725586 (Rps6kb2)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103725586 (Rps6kb2)
   05205 Proteoglycans in cancer
    103725586 (Rps6kb2)
   05231 Choline metabolism in cancer
    103725586 (Rps6kb2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103725586 (Rps6kb2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103725586 (Rps6kb2)
   05212 Pancreatic cancer
    103725586 (Rps6kb2)
   05225 Hepatocellular carcinoma
    103725586 (Rps6kb2)
   05226 Gastric cancer
    103725586 (Rps6kb2)
   05221 Acute myeloid leukemia
    103725586 (Rps6kb2)
   05224 Breast cancer
    103725586 (Rps6kb2)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    103725586 (Rps6kb2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    103725586 (Rps6kb2)
   05163 Human cytomegalovirus infection
    103725586 (Rps6kb2)
   05165 Human papillomavirus infection
    103725586 (Rps6kb2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103725586 (Rps6kb2)
   01522 Endocrine resistance
    103725586 (Rps6kb2)
Enzymes [BR:ngi01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     103725586 (Rps6kb2)
Protein kinases [BR:ngi01001]
Serine/threonine kinases: AGC group
  RSK family [OT]
   103725586 (Rps6kb2)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Pkinase_C Pkinase_fungal Kinase-like Seadorna_VP7 Kdo

Other DBs

NCBI-GeneID:

103725586

NCBI-ProteinID:

XP_008821112

LinkDB

Position

AA seq 485 aa
MAAVFDLDLETEEGSEAEGEPEFSPADVCPLAELRTAGLEPMGHYEEVELTESSVNLGPE
RIGPHCFELLSVLGKGGYGKVFQVRKVQGTNLGRIYAMKVLRKAKIVRNAKDTAHTRAER
NILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLGEITL
ALGHLHSQGIIYRDLKPENIMLNSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEI
LVHSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGKLVLPPYLTPDARDLA
KKFLKRNPIQRIGGGPGDAAEVQKHPFFRHINWDDLLARRVDPPFRPSLQSEEDVSQFDA
RFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRT
PISPLKFSPFEGFRPSPGPPEPMEPPLPPLLPPPSPPPPTSTAPLPIRPPSGIKKSKKSR
GRPGR

NT seq 1458 nt +upstreamnt +downstreamnt
atggcggccgtgtttgatctagacctggagaccgaggaaggcagcgaggcggagggcgag
ccagagttcagccctgcggacgtgtgtcccctcgccgagttgaggactgctggtttggag
cctatgggacactatgaggaggtggagctgacagagagcagcgtgaacctgggtcctgag
cgcattgggccccactgctttgaactcctgagtgtgcttggcaaggggggctatggcaag
gtgttccaggtgcgaaaggtgcaaggcaccaacttgggcagaatatatgccatgaaagtt
ctgaggaaggccaagattgtgcgcaatgccaaggacacagcacacacccgggctgagcgg
aacattctagaatctgtgaagcatcccttcattgtagaactggcctatgctttccagaca
ggtggcaaactctacctcatcctggagtgcctcagtggtggcgaactcttcacgcatctg
gagcgagaaggcatcttcctggaagacacagcctgcttctacctgggcgagatcacactg
gccctgggccatctccattcccaaggcatcatctacagggacctcaagccagagaacatc
atgctcaacagccagggccatatcaaactgacagactttggactctgcaaagagtccatc
catgaaggcgctgtcactcacaccttctgtggcactattgagtacatggcccctgagatt
ctggtgcacagtggccacaaccgggcagtggactggtggagcctgggggccctgatgtac
gacatgctcactggatcgccgcccttcaccgcagagaatcggaagaaaaccatggataag
atcatcaaaggaaagctggtgctgcccccctacctcaccccagatgcccgggaccttgcc
aaaaagtttctgaagcggaatcccatccagcggattgggggtggtccaggagatgctgct
gaggtacagaagcacccctttttccggcacatcaactgggatgacctcctggcccgccgc
gtggaccctcccttcaggccaagcctgcagtcagaagaggacgtgagccagtttgacgcc
cgcttcacacggcagactccagtggacagtccagatgacacagccctcagtgagagtgcc
aaccaagccttcctgggcttcacatatgtggcaccctctgtcctggacagcatcaaggag
ggtttctccttccagcctaagctgcgctcacccaggcgtctcaacagcagtccccgcacc
cctatcagccccctcaagttctctccctttgaggggttccggcccagccctggcccacca
gagcccatggagccacctctacctccacttctgccgccaccatcaccaccaccacccaca
agcactgccccccttcccatccgtcccccctcagggatcaagaaatccaagaagagccga
ggacgcccaggccgctag

Nannospalax galili (Upper Galilee mountains blind mole rat): 103741760

Entry

103741760 CDS T03372

Gene name

Rps6kb1

Definition

(RefSeq) ribosomal protein S6 kinase B1

K04688

ribosomal protein S6 kinase beta [EC:2.7.11.1]

Organism

ngi Nannospalax galili (Upper Galilee mountains blind mole rat)

Pathway

ngi01521

EGFR tyrosine kinase inhibitor resistance

ngi01522

Endocrine resistance

ngi04012

ErbB signaling pathway

ngi04066

HIF-1 signaling pathway

ngi04140

Autophagy - animal

ngi04150

mTOR signaling pathway

ngi04151

PI3K-Akt signaling pathway

ngi04152

AMPK signaling pathway

ngi04211

Longevity regulating pathway

ngi04213

Longevity regulating pathway - multiple species

ngi04350

TGF-beta signaling pathway

ngi04371

Apelin signaling pathway

ngi04666

Fc gamma R-mediated phagocytosis

ngi04714

Thermogenesis

ngi04910

Insulin signaling pathway

ngi04931

Insulin resistance

ngi05163

Human cytomegalovirus infection

ngi05165

Human papillomavirus infection

ngi05170

Human immunodeficiency virus 1 infection

ngi05200

Pathways in cancer

ngi05205

Proteoglycans in cancer

ngi05210

Colorectal cancer

ngi05212

Pancreatic cancer

ngi05221

Acute myeloid leukemia

ngi05224

Breast cancer

ngi05225

Hepatocellular carcinoma

ngi05226

Gastric cancer

ngi05231

Choline metabolism in cancer

ngi05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

Brite

KEGG Orthology (KO) [BR:ngi00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    103741760 (Rps6kb1)
   04350 TGF-beta signaling pathway
    103741760 (Rps6kb1)
   04371 Apelin signaling pathway
    103741760 (Rps6kb1)
   04066 HIF-1 signaling pathway
    103741760 (Rps6kb1)
   04151 PI3K-Akt signaling pathway
    103741760 (Rps6kb1)
   04152 AMPK signaling pathway
    103741760 (Rps6kb1)
   04150 mTOR signaling pathway
    103741760 (Rps6kb1)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103741760 (Rps6kb1)
09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    103741760 (Rps6kb1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103741760 (Rps6kb1)
  09149 Aging
   04211 Longevity regulating pathway
    103741760 (Rps6kb1)
   04213 Longevity regulating pathway - multiple species
    103741760 (Rps6kb1)
  09159 Environmental adaptation
   04714 Thermogenesis
    103741760 (Rps6kb1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103741760 (Rps6kb1)
   05205 Proteoglycans in cancer
    103741760 (Rps6kb1)
   05231 Choline metabolism in cancer
    103741760 (Rps6kb1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103741760 (Rps6kb1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103741760 (Rps6kb1)
   05212 Pancreatic cancer
    103741760 (Rps6kb1)
   05225 Hepatocellular carcinoma
    103741760 (Rps6kb1)
   05226 Gastric cancer
    103741760 (Rps6kb1)
   05221 Acute myeloid leukemia
    103741760 (Rps6kb1)
   05224 Breast cancer
    103741760 (Rps6kb1)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    103741760 (Rps6kb1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    103741760 (Rps6kb1)
   05163 Human cytomegalovirus infection
    103741760 (Rps6kb1)
   05165 Human papillomavirus infection
    103741760 (Rps6kb1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103741760 (Rps6kb1)
   01522 Endocrine resistance
    103741760 (Rps6kb1)
Enzymes [BR:ngi01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     103741760 (Rps6kb1)
Protein kinases [BR:ngi01001]
Serine/threonine kinases: AGC group
  RSK family [OT]
   103741760 (Rps6kb1)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Pkinase_C Kinase-like Pkinase_fungal APH

Other DBs

NCBI-GeneID:

103741760

NCBI-ProteinID:

XP_008840881

LinkDB

Position

AA seq 525 aa
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERSILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL

NT seq 1578 nt +upstreamnt +downstreamnt
atgaggcgacgacggaggcgggacggcttctacccagcgcctgacttccgagacagggaa
gctgaggacatggcaggagtgtttgacatagacctggaccagccagaggacgcaggctct
gaggatgagctggaggaggggggtcagttaaacgaaagcatggaccatgggggcgttgga
ccatatgaacttggcatggaacattgtgagaaatttgaaatatcagaaactagtgtgaac
cgagggccagaaaaaatcagaccagaatgctttgagctacttcgggtacttggtaaaggg
ggctatggaaaggtttttcaagtacgaaaagtaacaggagcaaatactggaaagatattt
gccatgaaggtgcttaaaaaggcaatgatagtaagaaatgctaaagacacagctcataca
aaggcagagcggagtattctggaggaagtaaagcatcccttcattgtggacttaatttat
gcctttcagaccggtggaaaactctacctcatccttgagtatctcagtggaggagaacta
tttatgcagttagaaagagagggaatatttatggaagacacggcttgtttttacttggct
gaaatctccatggctttggggcatttacatcaaaaggggatcatctacagagacctgaag
ccggagaacatcatgcttaatcaccaaggtcacgtgaaattaacagactttggactatgc
aaagaatctattcatgatggaacagtcacacacacattttgtggaacaatagaatacatg
gcccctgaaatcttgatgagaagtggccacaatcgcgctgtggattggtggagtttggga
gcattaatgtatgacatgctgactggagcacctccattcaccggggagaacagaaagaaa
acaattgacaaaatcctcaaatgtaaacttaatttgcctccctacctcacacaagaagct
agagatctgcttaaaaagctgctgaagagaaatgctgcttctcgacttggagctggtcct
ggggatgctggagaagtccaagctcatccatttttcagacacattaactgggaagaactc
ctggctcggaaggtggagcccccctttaaaccgctactgcaatctgaagaggatgtgagt
cagtttgattcaaagtttacacgccagacacctgttgacagcccagatgactcaactctc
agtgaaagtgccaaccaggtctttctgggttttacatatgtggctccatctgtacttgaa
agcgtgaaagaaaagttttcctttgaaccaaaaatccggtcacctcgaagatttattggt
agcccacgaacaccagtcagcccagtcaaattctctcctggggatttctggggaagaggt
gcttcagccagcacggcaaatcctcagacacctgtggagtacccaatggaaacaagcgga
atagagcagatggatgtgactatgagtggggaagcgtcagcaccacttccaatccgacag
ccgaactccgggccatacaaaaaacaagcttttcctatgatctccaaacggccagagcac
ctgcgtatgaatctatga

DBGET integrated database retrieval system