Nannospalax galili (Upper Galilee mountains blind mole rat): 103725694
Help
Entry
103725694 CDS
T03372
Definition
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
ngi
Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi00562
Inositol phosphate metabolism
ngi01100
Metabolic pathways
ngi01521
EGFR tyrosine kinase inhibitor resistance
ngi04012
ErbB signaling pathway
ngi04014
Ras signaling pathway
ngi04020
Calcium signaling pathway
ngi04062
Chemokine signaling pathway
ngi04064
NF-kappa B signaling pathway
ngi04066
HIF-1 signaling pathway
ngi04070
Phosphatidylinositol signaling system
ngi04072
Phospholipase D signaling pathway
ngi04360
Axon guidance
ngi04370
VEGF signaling pathway
ngi04380
Osteoclast differentiation
ngi04611
Platelet activation
ngi04613
Neutrophil extracellular trap formation
ngi04625
C-type lectin receptor signaling pathway
ngi04650
Natural killer cell mediated cytotoxicity
ngi04662
B cell receptor signaling pathway
ngi04664
Fc epsilon RI signaling pathway
ngi04666
Fc gamma R-mediated phagocytosis
ngi04670
Leukocyte transendothelial migration
ngi04722
Neurotrophin signaling pathway
ngi04750
Inflammatory mediator regulation of TRP channels
ngi04919
Thyroid hormone signaling pathway
ngi04933
AGE-RAGE signaling pathway in diabetic complications
ngi04935
Growth hormone synthesis, secretion and action
ngi05167
Kaposi sarcoma-associated herpesvirus infection
ngi05169
Epstein-Barr virus infection
ngi05170
Human immunodeficiency virus 1 infection
ngi05171
Coronavirus disease - COVID-19
ngi05200
Pathways in cancer
ngi05205
Proteoglycans in cancer
ngi05206
MicroRNAs in cancer
ngi05214
Glioma
ngi05223
Non-small cell lung cancer
ngi05225
Hepatocellular carcinoma
Module
ngi_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
ngi00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
103725694
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
103725694
04014 Ras signaling pathway
103725694
04370 VEGF signaling pathway
103725694
04064 NF-kappa B signaling pathway
103725694
04066 HIF-1 signaling pathway
103725694
04020 Calcium signaling pathway
103725694
04070 Phosphatidylinositol signaling system
103725694
04072 Phospholipase D signaling pathway
103725694
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
103725694
04613 Neutrophil extracellular trap formation
103725694
04625 C-type lectin receptor signaling pathway
103725694
04650 Natural killer cell mediated cytotoxicity
103725694
04662 B cell receptor signaling pathway
103725694
04664 Fc epsilon RI signaling pathway
103725694
04666 Fc gamma R-mediated phagocytosis
103725694
04670 Leukocyte transendothelial migration
103725694
04062 Chemokine signaling pathway
103725694
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
103725694
04919 Thyroid hormone signaling pathway
103725694
09156 Nervous system
04722 Neurotrophin signaling pathway
103725694
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
103725694
09158 Development and regeneration
04360 Axon guidance
103725694
04380 Osteoclast differentiation
103725694
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
103725694
05206 MicroRNAs in cancer
103725694
05205 Proteoglycans in cancer
103725694
09162 Cancer: specific types
05225 Hepatocellular carcinoma
103725694
05214 Glioma
103725694
05223 Non-small cell lung cancer
103725694
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
103725694
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
103725694
05171 Coronavirus disease - COVID-19
103725694
05167 Kaposi sarcoma-associated herpesvirus infection
103725694
05169 Epstein-Barr virus infection
103725694
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
103725694
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
ngi04131
]
103725694
Enzymes [BR:
ngi01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
103725694
Membrane trafficking [BR:
ngi04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
103725694
Endocytosis
Macropinocytosis
Phospholipase C
103725694
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
PI-PLC-Y
SH2
PH
PH_12
C2
EF-hand_like
Motif
Other DBs
NCBI-GeneID:
103725694
NCBI-ProteinID:
XP_017651059
LinkDB
All DBs
Position
Un
AA seq
920 aa
AA seq
DB search
MKYRAIVVSKRMTPFGKDQNSVSSEIMPAERIIEDNPLGSLCRGILDLNTYNVVKAAQGK
NQKPFIFILEPKKQGDPPMEFATDRVEELFEWFQSIREITWKMDTKENNMRYWEKNQSIA
IELSGLVVYCKPTSKTKDHLENPDFREIRSFVEMKANSIVRQKLGDLLWYNHKGLTRVYP
KGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRSDK
YDPMSPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVTTP
SRSQHALTLPCADHHAKVGLWSEESAAGVWIHSEMDIMEIKEICPGRSCKDFERAKAVHH
QEDCCFTILYGTQFVLNTLSLATDSKEDAVKWLSGLKILHQEAMSASTPTMIESWLRKQI
YSVDQTRRNRSCCCCGNTENQKIHLFRETLETFSKEPLAEAPQKEQLTQEICAHKDDLSF
EQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLQDFQRFLLHEQQELWA
QDLSKVRERMTKFIDDTMRETSEPFLFVDEFLTYLFSXENSIWDEKYNVVDMQDMNNPLY
LTRDQLRSESSIEAYIRCLRAGCHCIELGCLDGPDGKPIIYHGWTRTTKIKFDDVVQAIR
DHAFVSSSFPVILSIEEHCSVEQQRHMAKVFKEVLGDLLLTKPTEASADQLPSPCQLREK
IIIKKWTRHYCAIADAKLSFSDDIEQNVEEELVQDTPPTELHFGKKWFHKKVERRTSAEK
LLQEYCAEMGAKDGTFLVQESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTMKYYLTDNT
MFNSIYALIQHYRETHLHCAEFELRLTDPVPNPNPHESKPWYYDRLSRGEAEDMLMWIPR
DGAFLIRKREGTDSYVITFR
NT seq
2763 nt
NT seq
+upstream
nt +downstream
nt
atgaagtaccgagctattgttgtaagcaagagaatgacgccctttggaaaggaccagaac
agtgtcagttccgagatcatgccggccgaaagaattattgaagacaacccccttgggtct
ctctgcagaggtattttggacctcaatacctacaatgtcgtgaaggccgctcaggggaaa
aaccagaaaccattcatcttcatcctggagcccaagaagcagggggaccctcccatggag
ttcgccacagaccgtgtggaggagctgttcgaatggtttcagagcatccgggagatcacg
tggaagatggatacaaaggagaacaacatgaggtactgggaaaagaaccagtccatcgcc
attgagctctccggcctggttgtctactgcaagccaaccagcaaaaccaaggaccatttg
gaaaaccccgacttccgagaaatccgctccttcgtagagatgaaggccaacagcattgtc
agacagaagctgggagatctcctgtggtacaatcacaagggcctgacccgagtctaccca
aagggacagagagttgactcttcaaactatgaccccttccggctatggctctgtggctcc
cagatggtagcgctcaatttccagactgcagacaagtacatgcaaatgaaccatgcgttg
ttttcgctcaatgggcggacgggctacgtcctgcagcccgagagcatgcggtctgacaag
tacgacccgatgtccccagagtcgcaaaggaagatcttgatgactctcaccgtcaaggtt
cttggcgcacgccacctccccaaacttgggcggagtattgcctgtccctttgtagaggtg
gaaatctgtggagccgaatatgacaacaacaagtttaagacaacggttgtgacaactcct
tcaagatcccaacatgcgctgaccctgccatgtgccgaccaccatgccaaggtggggctg
tggtctgaggaaagtgctgcaggtgtttggattcactctgagatggacatcatggagata
aaggaaatctgcccagggaggagctgtaaggacttcgagcgtgccaaggccgtccatcac
caagaggactgctgcttcaccatcctctatggcacccagttcgtcctcaacacgctcagt
ctggcaaccgactcgaaggaggacgcagtgaagtggttgtctggcttgaagatcctccac
caggaagccatgagcgcatctactcccaccatgatcgagagttggctgagaaagcagatt
tattcagtggatcaaaccagaagaaacaggtcctgctgctgctgtggcaacacggaaaat
cagaaaatccaccttttccgagagaccctagagacattttcaaaagaacctttggccgaa
gcaccccagaaagagcagctgacacaagaaatctgtgcacacaaagacgacctcagtttt
gaacagttccatctcttctataaaaaacttatgtttgagcagcaaaaatcgatactcgac
gaattcaagaaggactcctctgtgttcatcctggggaacacagaccggccagatgcatct
gctgtctacctgcaggacttccagaggtttctcttacatgaacagcaggagctttgggct
caggatttaagcaaagtccgggagcggatgaccaagtttattgacgatacgatgagggaa
acctcagagcccttcttgtttgtggatgagttcctcacatacctgttctcatgagaaaac
agcatctgggatgagaaatacaacgtggtggacatgcaggacatgaacaaccccttgtac
ctcaccagggaccagctgcgcagcgagtcgtccatagaggcgtacatccgctgcctgcgt
gccggctgccattgcattgaattgggctgcttggatgggcctgatggaaaacccatcatc
taccacggctggacgcggaccaccaagatcaagtttgatgatgttgtgcaagccatccgg
gaccatgcctttgtttcctccagcttccctgtgatcctgtccatcgaggagcactgcagc
gtcgagcagcagcgccacatggctaaggtgttcaaggaggtgttgggagatctgctgctg
acaaagcccacggaggccagtgccgaccagctgccctcaccctgccagctgcgagagaag
atcatcatcaagaaatggactcgccactactgtgccattgctgacgccaagctgtccttt
agcgatgacattgaacagaatgtggaggaggagctggttcaggatactccccctacagag
ctgcattttgggaagaagtggttccataagaaggtggagaggaggaccagcgctgaaaaa
ctcctgcaggagtactgtgccgagatgggggccaaggacggcaccttcctggtgcaggag
agcgagaccttccccaacgactacaccttgtctttctggcggtcaggccgtgtgcagcac
tgcaggatccgctccaccatggaaggcggaaccatgaagtactacctgacagacaacacc
atgttcaacagcatctacgccctcattcagcactaccgggaaacacacctgcattgtgcg
gagttcgagcttcggcttaccgacccagtgcccaaccccaacccgcatgagtctaagcca
tggtactacgacaggctgagccggggggaggcagaggacatgctgatgtggatccccaga
gatggagccttcctcatccggaagcgggaggggactgactcctacgtcatcaccttcagg
tag
Nannospalax galili (Upper Galilee mountains blind mole rat): 103747244
Help
Entry
103747244 CDS
T03372
Gene name
Plcg1
Definition
(RefSeq) phospholipase C gamma 1
KO
K01116
phosphatidylinositol phospholipase C, gamma-1 [EC:
3.1.4.11
]
Organism
ngi
Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi00562
Inositol phosphate metabolism
ngi01100
Metabolic pathways
ngi01521
EGFR tyrosine kinase inhibitor resistance
ngi04012
ErbB signaling pathway
ngi04014
Ras signaling pathway
ngi04015
Rap1 signaling pathway
ngi04020
Calcium signaling pathway
ngi04062
Chemokine signaling pathway
ngi04064
NF-kappa B signaling pathway
ngi04066
HIF-1 signaling pathway
ngi04070
Phosphatidylinositol signaling system
ngi04072
Phospholipase D signaling pathway
ngi04360
Axon guidance
ngi04370
VEGF signaling pathway
ngi04613
Neutrophil extracellular trap formation
ngi04650
Natural killer cell mediated cytotoxicity
ngi04658
Th1 and Th2 cell differentiation
ngi04659
Th17 cell differentiation
ngi04660
T cell receptor signaling pathway
ngi04664
Fc epsilon RI signaling pathway
ngi04666
Fc gamma R-mediated phagocytosis
ngi04670
Leukocyte transendothelial migration
ngi04722
Neurotrophin signaling pathway
ngi04750
Inflammatory mediator regulation of TRP channels
ngi04919
Thyroid hormone signaling pathway
ngi04933
AGE-RAGE signaling pathway in diabetic complications
ngi04935
Growth hormone synthesis, secretion and action
ngi05012
Parkinson disease
ngi05022
Pathways of neurodegeneration - multiple diseases
ngi05135
Yersinia infection
ngi05167
Kaposi sarcoma-associated herpesvirus infection
ngi05170
Human immunodeficiency virus 1 infection
ngi05171
Coronavirus disease - COVID-19
ngi05200
Pathways in cancer
ngi05205
Proteoglycans in cancer
ngi05206
MicroRNAs in cancer
ngi05214
Glioma
ngi05223
Non-small cell lung cancer
ngi05225
Hepatocellular carcinoma
ngi05231
Choline metabolism in cancer
ngi05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Module
ngi_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
ngi00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
103747244 (Plcg1)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
103747244 (Plcg1)
04014 Ras signaling pathway
103747244 (Plcg1)
04015 Rap1 signaling pathway
103747244 (Plcg1)
04370 VEGF signaling pathway
103747244 (Plcg1)
04064 NF-kappa B signaling pathway
103747244 (Plcg1)
04066 HIF-1 signaling pathway
103747244 (Plcg1)
04020 Calcium signaling pathway
103747244 (Plcg1)
04070 Phosphatidylinositol signaling system
103747244 (Plcg1)
04072 Phospholipase D signaling pathway
103747244 (Plcg1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
103747244 (Plcg1)
04650 Natural killer cell mediated cytotoxicity
103747244 (Plcg1)
04660 T cell receptor signaling pathway
103747244 (Plcg1)
04658 Th1 and Th2 cell differentiation
103747244 (Plcg1)
04659 Th17 cell differentiation
103747244 (Plcg1)
04664 Fc epsilon RI signaling pathway
103747244 (Plcg1)
04666 Fc gamma R-mediated phagocytosis
103747244 (Plcg1)
04670 Leukocyte transendothelial migration
103747244 (Plcg1)
04062 Chemokine signaling pathway
103747244 (Plcg1)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
103747244 (Plcg1)
04919 Thyroid hormone signaling pathway
103747244 (Plcg1)
09156 Nervous system
04722 Neurotrophin signaling pathway
103747244 (Plcg1)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
103747244 (Plcg1)
09158 Development and regeneration
04360 Axon guidance
103747244 (Plcg1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
103747244 (Plcg1)
05206 MicroRNAs in cancer
103747244 (Plcg1)
05205 Proteoglycans in cancer
103747244 (Plcg1)
05231 Choline metabolism in cancer
103747244 (Plcg1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
103747244 (Plcg1)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
103747244 (Plcg1)
05214 Glioma
103747244 (Plcg1)
05223 Non-small cell lung cancer
103747244 (Plcg1)
09164 Neurodegenerative disease
05012 Parkinson disease
103747244 (Plcg1)
05022 Pathways of neurodegeneration - multiple diseases
103747244 (Plcg1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
103747244 (Plcg1)
09171 Infectious disease: bacterial
05135 Yersinia infection
103747244 (Plcg1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
103747244 (Plcg1)
05171 Coronavirus disease - COVID-19
103747244 (Plcg1)
05167 Kaposi sarcoma-associated herpesvirus infection
103747244 (Plcg1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
103747244 (Plcg1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
ngi04131
]
103747244 (Plcg1)
Enzymes [BR:
ngi01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
103747244 (Plcg1)
Membrane trafficking [BR:
ngi04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
103747244 (Plcg1)
Endocytosis
Macropinocytosis
Phospholipase C
103747244 (Plcg1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
C2
SH3_1
PH
SH3_9
SH3_2
PH_12
GDPD
PH_9
Motif
Other DBs
NCBI-GeneID:
103747244
NCBI-ProteinID:
XP_008847808
LinkDB
All DBs
Position
Un
AA seq
1291 aa
AA seq
DB search
MAGATTPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRT
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLNTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLSRAQAEHMLMRVPRDGAFLVRKRNEANSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLW
FPSNYVEEMISPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCVICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFHINNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDVFPAKQENGDLSPFGGTSLRERVSDASSQLFHGRAREGSFEARYQQPFED
FRISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq
3876 nt
NT seq
+upstream
nt +downstream
nt
atggcgggcgccacgaccccctgcgccaatggctgcgggcccggcgcgccctccgatgcc
gaggtgttgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggccggaacggaagaccttccaggtcaaactggagacgcgccagatc
acgtggagccgcggcgccgacaagatcgagggggccattgatattcgtgaaatcaaagag
atccgcccagggaagacttctcgagactttgaccgctaccaagaagaccctgctttccgg
ccagaccagtcacactgctttgtcatcctctatggaatggaattccgcctgaagacccta
agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggctg
atggaggacacattgcaggcagccacacccctgcagattgagaggtggctccggaaacag
ttctactcagtggaccggaaccgtgaggatcgtatatcagccaaggacctgaagaacatg
ttgtcacaagtcaattatcgggtccccaacatgcgcttcctccgagaacggctgacggac
ctggaacagcgcagcggggacatcacctatggacagtttgctcagctgtaccgcagcctc
atgtacagcgcacagaagacgatggacctccccttcttggaagccagcactttgagaact
ggggagcggccagagctctgtcgggtatctcttcccgagttccagcagtttctccttgag
taccagggggaactatgggcagttgaccgccttcaggtgcaggaattcatgctcagtttc
ctcagagaccccttgcgagagattgaggaaccatacttctttttggatgagtttgttacc
tttctgttctccaaagagaacagtgtgtggaactcccagctggatgccgtgtgcccagac
accatgaacaaccctctctcccactactggatctcgtcctcgcataacacgtacctgact
ggggaccagttctccagcgaatcctcactggaagcttatgctcgctgcctgaggatgggc
tgtcgctgcattgagttggattgctgggacggcccagatgggatgccagtcatttaccac
gggcatacccttaccaccaagatcaagttctcagatgtcctgaacacaatcaaggagcat
gctttcgtggcctcagagtacccagtcatcctgtccattgaggaccactgcagcattgcc
cagcagaggaacatggcccagtacttcaagaaggtgcttggggacacactcctcaccaag
cctgtggacattgccgctgatgggctcccctcacccaaccagctcaaaaggaagattctt
attaagcacaagaagctggccgagggcagtgcctatgaggaagtgcctacttctgtgatg
tactctgagaatgacatcagcaactccatcaagaatggcatcctctacctggaagaccct
gtgaaccatgaatggtatccccactacttcgttctgaccagcagcaagatctactactct
gaggagacaagcagtgaccagggcaatgaggatgaagaggagccaaaggaggccagtggg
agcacagaactgcactccaatgagaagtggttccatgggaagctcggggctggacgagat
gggcggcacattgctgagcgcctcctcaccgagtactgcattgagaccggggctcctgat
ggctccttcctagtgcgagaaagcgagacctttgtgggcgactacacactgtctttctgg
cggaatgggaaagtccagcactgccgtatccactctcgacaggatgccggtacccccaag
ttcttcttgacagataaccttgtctttgactccctctatgacctcatcacacactatcag
caggtgccacttcgctgcaatgagtttgagatgcgcctttcagagcctgttccacagaca
aatgcccacgagagcaaagagtggtaccatgcaagcctgtcgagagctcaggctgaacac
atgctgatgcgtgtaccacgtgatggggctttcctggtgcggaaacggaatgaggccaac
tcatacgctatctccttccgggctgagggaaagataaagcactgccgagtccagcaggag
ggccaaactgtgatgctggggaactccgagttcgacagccttgtcgacctcatcagctac
tacgagaagcaccccctgtaccgcaaaatgaagttgcgctaccccatcaacgaggaggca
ctggagaagattggcacagcagagcctgattacggggcactgtatgaaggccgcaaccct
ggcttctatgtggaggcaaaccccatgccaactttcaagtgtgcagtcaaagccctcttt
gactacaaggcccagagagaggatgagctgaccttcaccaagagtgccatcatccagaat
gtagagaagcaagatggtggctggtggcgaggggactatggtgggaagaagcagctgtgg
ttcccttcaaactacgtggaagagatgatcagcccagcagccctggagccagagagggag
cacctggacgagaacagccccctgggggacttgctgcggggggtcttggatgtgccagcc
tgtcagattgccattcgtcctgagggcaagaacaaccggctgttcgtgttctccatcagc
atggcatcagtggctcactggtccctagatgttgcagctgactcgcaggaggagttgcag
gactgggtgaaaaagatccgggaagtggcccagactgcagatgccaggcttactgagggg
aagatgatggaacggaggaagaagatcgccttggagctttctgagctcgtggtctactgc
cggcctgttccgtttgatgaagagaagattggcacagaacgagcctgttaccgggacatg
tcatcctttccggaaaccaaagctgagaagtacgtgaacaaggccaaaggcaagaagttc
ctccagtacaatcgcctgcagctctcccgcatctaccccaagggccagcgactggactcc
tccaattacgatcctctgcccatgtggatctgtggcagtcagcttgtggctctcaatttc
cagaccccagacaagcctatgcagatgaaccaggccctcttcatggccggtggacactgt
ggctacgtgctgcagccaagcaccatgagagatgaagcctttgacccctttgacaagagc
agcctccgaggactggagccctgtgtcatctgcattgaggtgctgggggcccggcatctg
ccaaagaatggccgaggcattgtgtgtccttttgtggagattgaggtggctggagcagag
tatgacagcaccaagcaaaaaacagagtttgtagtggacaatgggctgaaccctgtgtgg
ccagccaagcccttccacttccatatcaataaccctgaatttgccttcctgcgctttgtg
gtgtatgaagaagacatgtttagtgaccagaacttcttagctcaggctactttcccagtg
aaaggcctgaagacaggctatagagcagtgcctctgaaaaacaactacagtgaagacctg
gagttggcctccctgctcatcaagattgacgttttccctgccaagcaggagaacggtgac
ctcagtccctttggtggtacatccctgcgggaacgggtctctgatgcctcaagccagctg
tttcatgggcgggctcgggaaggctcctttgaagcccgctatcaacagccatttgaagac
ttccgcatctcccaggagcatctcgcagatcattttgacagtcgagaacgaagggcccca
agaaggactcgggtcaacggagacaaccgcctctag
Nannospalax galili (Upper Galilee mountains blind mole rat): 103748739
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Entry
103748739 CDS
T03372
Definition
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
ngi
Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi00562
Inositol phosphate metabolism
ngi01100
Metabolic pathways
ngi01521
EGFR tyrosine kinase inhibitor resistance
ngi04012
ErbB signaling pathway
ngi04014
Ras signaling pathway
ngi04020
Calcium signaling pathway
ngi04062
Chemokine signaling pathway
ngi04064
NF-kappa B signaling pathway
ngi04066
HIF-1 signaling pathway
ngi04070
Phosphatidylinositol signaling system
ngi04072
Phospholipase D signaling pathway
ngi04360
Axon guidance
ngi04370
VEGF signaling pathway
ngi04380
Osteoclast differentiation
ngi04611
Platelet activation
ngi04613
Neutrophil extracellular trap formation
ngi04625
C-type lectin receptor signaling pathway
ngi04650
Natural killer cell mediated cytotoxicity
ngi04662
B cell receptor signaling pathway
ngi04664
Fc epsilon RI signaling pathway
ngi04666
Fc gamma R-mediated phagocytosis
ngi04670
Leukocyte transendothelial migration
ngi04722
Neurotrophin signaling pathway
ngi04750
Inflammatory mediator regulation of TRP channels
ngi04919
Thyroid hormone signaling pathway
ngi04933
AGE-RAGE signaling pathway in diabetic complications
ngi04935
Growth hormone synthesis, secretion and action
ngi05167
Kaposi sarcoma-associated herpesvirus infection
ngi05169
Epstein-Barr virus infection
ngi05170
Human immunodeficiency virus 1 infection
ngi05171
Coronavirus disease - COVID-19
ngi05200
Pathways in cancer
ngi05205
Proteoglycans in cancer
ngi05206
MicroRNAs in cancer
ngi05214
Glioma
ngi05223
Non-small cell lung cancer
ngi05225
Hepatocellular carcinoma
Module
ngi_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
ngi00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
103748739
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
103748739
04014 Ras signaling pathway
103748739
04370 VEGF signaling pathway
103748739
04064 NF-kappa B signaling pathway
103748739
04066 HIF-1 signaling pathway
103748739
04020 Calcium signaling pathway
103748739
04070 Phosphatidylinositol signaling system
103748739
04072 Phospholipase D signaling pathway
103748739
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
103748739
04613 Neutrophil extracellular trap formation
103748739
04625 C-type lectin receptor signaling pathway
103748739
04650 Natural killer cell mediated cytotoxicity
103748739
04662 B cell receptor signaling pathway
103748739
04664 Fc epsilon RI signaling pathway
103748739
04666 Fc gamma R-mediated phagocytosis
103748739
04670 Leukocyte transendothelial migration
103748739
04062 Chemokine signaling pathway
103748739
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
103748739
04919 Thyroid hormone signaling pathway
103748739
09156 Nervous system
04722 Neurotrophin signaling pathway
103748739
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
103748739
09158 Development and regeneration
04360 Axon guidance
103748739
04380 Osteoclast differentiation
103748739
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
103748739
05206 MicroRNAs in cancer
103748739
05205 Proteoglycans in cancer
103748739
09162 Cancer: specific types
05225 Hepatocellular carcinoma
103748739
05214 Glioma
103748739
05223 Non-small cell lung cancer
103748739
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
103748739
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
103748739
05171 Coronavirus disease - COVID-19
103748739
05167 Kaposi sarcoma-associated herpesvirus infection
103748739
05169 Epstein-Barr virus infection
103748739
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
103748739
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
ngi04131
]
103748739
Enzymes [BR:
ngi01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
103748739
Membrane trafficking [BR:
ngi04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
103748739
Endocytosis
Macropinocytosis
Phospholipase C
103748739
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
C2
SH3_1
SH3_9
SH3_2
PH
GDPD
Motif
Other DBs
NCBI-GeneID:
103748739
NCBI-ProteinID:
XP_017658289
LinkDB
All DBs
Position
Un
AA seq
1054 aa
AA seq
DB search
ILDEFKKDSSVFILGALQHYTGSGLQLLRRPQDLVWMRVQYQLLELWAQDLNKVRERMTK
FIDDTMRETSEPFLFVDEFLTYLFSRENSIWDEKYNVVDMQDMNNPLSHYWISSSHNTYL
TGDQLRSESSTEAYIRCLRAGCRCIELDCWDGPDGKPIIYHGWTRTTKIKFDDVVQAIRD
HAFVSSSFPVILSIEEHCSVEQQRHMAKVFKEVLGDLLLTKPTEASADQLPSPCQLREKI
IIKHKKLGPRGDVDVNMEDKKDEHKTQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQ
NVEEELVQDTPPTELHFGEKWFHKKVERRTSAEKLLQEYCAETGAKDGTFLVRESETFPN
DYTLSFWRSGRVQHCRIRSTMEGGTMKYYLTDNTMFNSIYALIQHYRETHLHCAEFELRL
TDPVPNPNPHESKPWYYDRLSRGEAEDMLMRIPRDGAFLIRKREGTDSYAITFRAKGKVK
HCRINRDGRHFVLGTSAYFESLVELVNYYEKHALYRKMRLRYPVTPELLERYNMERDINS
LYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDY
GTRIQQYFPSNYVEDISAGDVEELEKQIIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKP
FVFILEPKKQGDPPVEFATDRVEELFEWFQSIREITWKMDTKENNMRYWEKNQSIAIELS
DLVVYCKPTSKTKDHLENPDFREIRSFVETKADSIVRQKPGDLLRYNHKGLTRVYPKGQR
VDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGQTGYILQPESMRSDKYDPM
SPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAKYDNNKFKTTVVNDNGLSP
VWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKGIKSGFRSVPLKNGY
SEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRGANRDAL
VKEFNVNENQLQLYQEKCNRRLREKRVSNSKFYS
NT seq
3165 nt
NT seq
+upstream
nt +downstream
nt
atactcgacgaattcaagaaggattcctctgtgttcatcctgggagccctccagcactac
acaggctctgggctgcagcttctgaggaggccccaggacctggtctggatgagggtccag
tatcagcttctagagctttgggctcaggatttaaacaaagtccgggagcggatgaccaag
tttattgacgatacgatgagggaaacctcagagcccttcttgtttgtggatgagttcctc
acatacctgttctcacgagaaaacagcatctgggatgagaaatacaacgtggtggacatg
caggacatgaacaaccccttgtcacattactggatctcttcctcccacaacacgtacctc
actggggaccagctgcgcagcgagtcgtccacagaggcgtacatccgctgcctgcgtgcc
ggctgccgttgcattgaattggactgctgggatgggcctgatggaaaacccatcatctac
cacggctggacgcggaccaccaagatcaagtttgatgatgtcgtgcaagccatccgggac
catgcctttgtttcctccagcttccctgtgatcctgtccatcgaggagcactgcagcgtc
gagcagcagcgccacatggctaaggtgttcaaggaggtgttgggagatctgctgctgaca
aagcccacggaggccagtgccgaccagctgccctcaccctgccagctgcgagagaagatc
atcatcaagcataagaagctgggtccccgaggcgatgttgatgtcaacatggaggacaag
aaggatgaacacaagactcagggcgagctgtacatgtgggactccatcgaccagaaatgg
actcgccactactgtgccattgctgacgccaagctgtcctttagcgatgacattgaacag
aatgtggaggaggagctggttcaggacactccccctacagagctgcattttggggagaag
tggttccataagaaggtggagaggaggaccagcgctgaaaaactcctgcaggagtactgt
gccgagacgggggccaaggacggcaccttcctggtgcgggagagcgagaccttccccaac
gactacaccttgtctttctggcggtcaggccgtgtgcagcactgcaggatccgctccacc
atggaaggcggaaccatgaagtactacctgacggacaacaccatgttcaacagcatctac
gccctcattcagcactaccgggaaacacacctgcattgtgcggagttcgagcttcggctt
accgacccagtgcccaaccccaacccgcatgagtctaagccatggtactatgacaggctg
agccggggggaggcagaggacatgctgatgcggatccccagagatggagccttcctcatc
cgtaagcgggaggggaccgactcctacgccatcaccttcagggccaagggcaaggtgaaa
cactgtcggattaaccgggatggccggcactttgtactggggacctctgcctactttgag
agcctcgtggagcttgtcaactactatgagaagcacgcgctctatcggaagatgaggctg
cgctacccggtgacccccgagctcctggagcgctacaatatggaaagagacatcaactct
ctttatgatgtcagcaggatgtatgtggacccgagtgagatcaacccttccatgcctcag
aggactgtgaaagcactctatgactacaaagccaaacgcagcgatgaactgagcttctgc
cggggtgccctcattcacaatgtctccaaggagcctgggggctggtggaaaggggactac
gggacccgaatccagcagtactttccatccaactacgtggaggacatttcagcaggtgat
gttgaagagttagagaagcagattattgaagacaacccccttgggtctctctgcagaggt
attttggacctcaatacctacaatgtcgtgaaggcccctcaggggaaaaaccagaaacca
ttcgtcttcatcctggagcccaagaagcagggggaccctcccgtggagttcgccacagac
cgtgtggaggagctgttcgaatggtttcagagcatccgggagatcacgtggaagatggat
acgaaggagaacaacatgaggtactgggaaaagaaccagtccatcgccattgagctctcc
gacctggttgtctactgcaagccaaccagcaaaaccaaggaccatttggaaaaccccgac
ttccgagaaatccgctccttcgtagagacgaaggccgacagcattgtcagacagaagccg
ggagatctcctgcggtacaatcacaagggcctgacccgagtctacccgaagggacagaga
gttgactcttcaaactatgaccccttccggctatggctctgcggctcccagatggtggcg
ctcaatttccagactgcagacaagtacatgcaaatgaaccatgcgttgttttcgctcaat
gggcagacgggctacatcctgcagcccgagagcatgcggtctgacaagtacgacccgatg
tccccagagtcgcaaaggaagatcttgatgactctcaccgtcaaggttcttggcgcacgc
cacctccccaaacttgggcggagtattgcctgtccctttgtagaggtggaaatctgtgga
gccaaatatgacaacaacaagtttaagacaacggttgtgaatgacaatggcctcagccct
gtctgggcaccaacacaggagaaggtgacctttgaaatttatgacccaaaccttgcgttt
ctgcgctttgtggtctatgaggaagacatgttcagtgaccccaacttcctggctcatgcc
acgtatcccattaaaggcatcaaatcagggttccgatcggtccccctgaagaacgggtac
agtgaagacattgagctggcttctctgctggttttctgtgagatgcggccagtcctggag
agcgaagaggaactctattcctcatgccgccagctacggaggcgacaagaggagctaaac
aaccagctcttcctgtacgacacacaccagaaccttcgaggcgccaaccgtgatgcccta
gtcaaggaattcaacgttaacgagaatcagctccagctttatcaggagaagtgcaaccgg
aggttgagagagaagagagttagcaacagcaagttctactcctag
DBGET
integrated database retrieval system
