Nannospalax galili (Upper Galilee mountains blind mole rat): 103726107
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Entry
103726107 CDS
T03372
Gene name
Braf
Definition
(RefSeq) B-Raf proto-oncogene, serine/threonine kinase
KO
K04365
B-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
ngi
Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi01521
EGFR tyrosine kinase inhibitor resistance
ngi01522
Endocrine resistance
ngi04010
MAPK signaling pathway
ngi04012
ErbB signaling pathway
ngi04015
Rap1 signaling pathway
ngi04024
cAMP signaling pathway
ngi04062
Chemokine signaling pathway
ngi04068
FoxO signaling pathway
ngi04150
mTOR signaling pathway
ngi04270
Vascular smooth muscle contraction
ngi04510
Focal adhesion
ngi04650
Natural killer cell mediated cytotoxicity
ngi04720
Long-term potentiation
ngi04722
Neurotrophin signaling pathway
ngi04726
Serotonergic synapse
ngi04730
Long-term depression
ngi04810
Regulation of actin cytoskeleton
ngi04910
Insulin signaling pathway
ngi04914
Progesterone-mediated oocyte maturation
ngi04928
Parathyroid hormone synthesis, secretion and action
ngi04934
Cushing syndrome
ngi05010
Alzheimer disease
ngi05022
Pathways of neurodegeneration - multiple diseases
ngi05034
Alcoholism
ngi05160
Hepatitis C
ngi05161
Hepatitis B
ngi05200
Pathways in cancer
ngi05205
Proteoglycans in cancer
ngi05210
Colorectal cancer
ngi05211
Renal cell carcinoma
ngi05212
Pancreatic cancer
ngi05213
Endometrial cancer
ngi05214
Glioma
ngi05215
Prostate cancer
ngi05216
Thyroid cancer
ngi05218
Melanoma
ngi05219
Bladder cancer
ngi05220
Chronic myeloid leukemia
ngi05221
Acute myeloid leukemia
ngi05223
Non-small cell lung cancer
ngi05224
Breast cancer
ngi05225
Hepatocellular carcinoma
ngi05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
ngi00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
103726107 (Braf)
04012 ErbB signaling pathway
103726107 (Braf)
04015 Rap1 signaling pathway
103726107 (Braf)
04068 FoxO signaling pathway
103726107 (Braf)
04024 cAMP signaling pathway
103726107 (Braf)
04150 mTOR signaling pathway
103726107 (Braf)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
103726107 (Braf)
09142 Cell motility
04810 Regulation of actin cytoskeleton
103726107 (Braf)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
103726107 (Braf)
04062 Chemokine signaling pathway
103726107 (Braf)
09152 Endocrine system
04910 Insulin signaling pathway
103726107 (Braf)
04914 Progesterone-mediated oocyte maturation
103726107 (Braf)
04928 Parathyroid hormone synthesis, secretion and action
103726107 (Braf)
09153 Circulatory system
04270 Vascular smooth muscle contraction
103726107 (Braf)
09156 Nervous system
04726 Serotonergic synapse
103726107 (Braf)
04720 Long-term potentiation
103726107 (Braf)
04730 Long-term depression
103726107 (Braf)
04722 Neurotrophin signaling pathway
103726107 (Braf)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
103726107 (Braf)
05205 Proteoglycans in cancer
103726107 (Braf)
09162 Cancer: specific types
05210 Colorectal cancer
103726107 (Braf)
05212 Pancreatic cancer
103726107 (Braf)
05225 Hepatocellular carcinoma
103726107 (Braf)
05226 Gastric cancer
103726107 (Braf)
05214 Glioma
103726107 (Braf)
05216 Thyroid cancer
103726107 (Braf)
05221 Acute myeloid leukemia
103726107 (Braf)
05220 Chronic myeloid leukemia
103726107 (Braf)
05218 Melanoma
103726107 (Braf)
05211 Renal cell carcinoma
103726107 (Braf)
05219 Bladder cancer
103726107 (Braf)
05215 Prostate cancer
103726107 (Braf)
05213 Endometrial cancer
103726107 (Braf)
05224 Breast cancer
103726107 (Braf)
05223 Non-small cell lung cancer
103726107 (Braf)
09164 Neurodegenerative disease
05010 Alzheimer disease
103726107 (Braf)
05022 Pathways of neurodegeneration - multiple diseases
103726107 (Braf)
09165 Substance dependence
05034 Alcoholism
103726107 (Braf)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
103726107 (Braf)
09172 Infectious disease: viral
05161 Hepatitis B
103726107 (Braf)
05160 Hepatitis C
103726107 (Braf)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
103726107 (Braf)
01522 Endocrine resistance
103726107 (Braf)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ngi01001
]
103726107 (Braf)
Enzymes [BR:
ngi01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
103726107 (Braf)
Protein kinases [BR:
ngi01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
103726107 (Braf)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
C1_2
Pkinase_fungal
APH
Kdo
Motif
Other DBs
NCBI-GeneID:
103726107
NCBI-ProteinID:
XP_008821740
LinkDB
All DBs
Position
Un
AA seq
798 aa
AA seq
DB search
MEPEAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEE
YTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDV
SRSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGY
GLEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRC
QTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAP
PSDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDE
KFPEVELQDQRDLIRDQGFRGDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGP
VFRGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDD
WEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTR
HVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHA
KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQD
KNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAM
KRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACA
SPKTPIQAGGYGEFAAFK
NT seq
2397 nt
NT seq
+upstream
nt +downstream
nt
atggagcccgaggccggcgcgggcgccgcggcctcctcggctgccgacccggccattcct
gaggaggtgtggaatatcaaacaaatgattaaattgacacaggaacatatagaagcccta
ttggacaaatttggtggggagcataatccaccatcaatatacttggaggcctatgaagaa
tacaccagcaagctagatgccctccaacaaagagaacaacagttattggaatccctgggg
aatggaactgatttttctgtttctagctctgcatcaatggacaccgttacatcctcttct
tcttctagcctttcagtgctaccttcatctctttcagtttttcaaaatcccacagatgta
tcacggagtaaccccaagtcaccacaaaaacctatcgttagagtcttcctgcccaacaaa
cagagaacagtggtacctgcaagatgtggagtgacagtccgagacagtctaaagaaagca
ctaatgatgagaggcctcatcccagagtgctgtgccgtttacagaattcaggatgggtat
ggtttagagaagaaaccaattggctgggacactgatatatcttggctgactggggaagag
ttacatgtggaagtattggagaatgtgccacttaccacacacaactttgtacggaaaacg
tttttcaccttagcattttgtgacttttgtcgaaagctgcttttccagggtttccgctgt
caaacatgtggttataagtttcaccaacgttgtagtacagaggttccactgatgtgtgtt
aattatgaccagcttgatttgctgtttgtctccaagttctttgagcatcacccaatacca
caggaagaggcctccttagcagagactgcccttacatctggatcatccccttctgcaccc
ccctcagactctattgggccccaaattctcaccagtccatctccttcaaaatccattcca
attccacagcccttccgaccagcagatgaagatcatcgaaatcagtttgggcaacgagac
cggtcctcctcagctcccaatgtgcatataaatacaatagaacctgtcaatattgatgaa
aaattcccagaagtggaattacaggatcaaagggatttgattagagaccaagggtttcgt
ggtgatggagcccccttgaaccagctgatgcgctgtcttcggaaataccaatcccggact
cccagccccctcctacattctgtccccagtgaaatagtgtttgattttgagcctggccca
gtgttcagagggtcaaccacaggtttgtctgccaccccacctgcctcattacctggctcc
ctcactaatgtgaaagccttacagaaatctccaggacctcagcgggaaaggaaatcatct
tcatcctcagaagatagaaatcgaatgaaaacacttggtagacgagattcaagtgatgat
tgggagattcctgatggacagattacagtgggacagagaattggatctgggtcatttgga
actgtctacaaaggaaagtggcatggtgatgtggcagtgaaaatgttgaatgtgacggca
cccacacctcaacagctacaagccttcaaaaatgaagtaggagtactcaggaaaacacga
catgtgaatatcctacttttcatgggctattcaacaaagccacaactggctattgttacg
cagtggtgtgaaggctccagcttgtatcaccatctccatatcattgagaccaaatttgag
atgatcaaacttatagatattgcacggcagactgcacagggcatggattacttacacgcc
aagtcaatcatccacagagacctcaagagtaataatatatttcttcatgaagacctcacg
gtaaaaataggtgattttggtctagccacagtgaaatctcgatggagtgggtcccatcag
tttgaacagttgtctggatccatcttgtggatggcaccagaagtaatcaggatgcaagat
aaaaacccatatagctttcagtcagatgtatatgcctttgggattgttctgtacgaactg
atgactggccagctaccttattcaaacatcaacaacagggatcagataatttttatggtg
ggacgaggatacctatctccagatctcagtaaggtacggagtaactgtccaaaagccatg
aagagattaatggcagagtgcctcaaaaagaaaagagatgaaagaccactctttccccaa
attctcgcctctattgagctgctggcccgctcattgccaaaaattcaccgcagtgcatca
gaaccctccttgaatcgggctggtttccagacagaagattttagtctgtacgcttgtgct
tctccaaaaacacccatccaagcagggggatatggagagtttgcagccttcaagtag
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