KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103729733Help
Entry
103729733         CDS       T03372                                 

Gene name
Hkdc1
Definition
(RefSeq) hexokinase domain containing 1
  KO
K00844  hexokinase [EC:2.7.1.1]
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi00010  Glycolysis / Gluconeogenesis
ngi00051  Fructose and mannose metabolism
ngi00052  Galactose metabolism
ngi00500  Starch and sucrose metabolism
ngi00520  Amino sugar and nucleotide sugar metabolism
ngi00524  Neomycin, kanamycin and gentamicin biosynthesis
ngi01100  Metabolic pathways
ngi01200  Carbon metabolism
ngi04066  HIF-1 signaling pathway
ngi04910  Insulin signaling pathway
ngi04930  Type II diabetes mellitus
ngi04973  Carbohydrate digestion and absorption
ngi05230  Central carbon metabolism in cancer
Module
ngi_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
ngi_M00549  Nucleotide sugar biosynthesis, glucose => UDP-glucose
Brite
KEGG Orthology (KO) [BR:ngi00001]
 Metabolism
  Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    103729733 (Hkdc1)
   00051 Fructose and mannose metabolism
    103729733 (Hkdc1)
   00052 Galactose metabolism
    103729733 (Hkdc1)
   00500 Starch and sucrose metabolism
    103729733 (Hkdc1)
   00520 Amino sugar and nucleotide sugar metabolism
    103729733 (Hkdc1)
  Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    103729733 (Hkdc1)
 Environmental Information Processing
  Signal transduction
   04066 HIF-1 signaling pathway
    103729733 (Hkdc1)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    103729733 (Hkdc1)
  Digestive system
   04973 Carbohydrate digestion and absorption
    103729733 (Hkdc1)
 Human Diseases
  Cancers
   05230 Central carbon metabolism in cancer
    103729733 (Hkdc1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    103729733 (Hkdc1)
Enzymes [BR:ngi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.1  hexokinase
     103729733 (Hkdc1)
Membrane trafficking [BR:ngi04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    103729733 (Hkdc1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Hexokinase_2 Hexokinase_1 VPS13_mid_rpt
Motif
Other DBs
NCBI-GeneID: 103729733
NCBI-ProteinID: XP_008826033
LinkDB All DBs
Position
Un
AA seq 911 aa AA seqDB search
MFAVHLMAFYFTKLKEDQIKKVDRFLYHMRLSDETLLDIMARFQAEMEKGLGKDTNPTAS
VKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVSEEGKRQVQMESQFYPTPNEIIR
GNGMELFDYVADCLADFMKTKELTHKKLPLGFTFSFPCRQTKLEEGVLLSWTKKFKARGV
QDTDVVSRLTNAMKRHKDLDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYME
DMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSINPGKQLFEKMISGL
YMGELVRLILLKMAKAGLLFGGAKSSALLMKGKIETQHVAAMERYKEGLANTREILVDLG
LDPSEADCIAVQHVCTIVSFRSANLCAAALAAILTRLQQNKKQARLRTTVGMDGTLYKIH
PQYPKRLHKVVRKLVPNCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDKVLALFQLT
QEQLLSVRDRMRTELEYGLKKKTHALATVKMLPTYVYGMPDGTEKGKFLALDLGGTNFRV
LLVKIRSGRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLEYMGLKGAQLPLGFT
FSFPCRQMSIDKGTLVGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVALVNDTVGT
MMTCGYEDPKCEIGLIAGTGSNVCYMEEMRNIELVEGDEGKMCINTEWGGFGDNGCIDDI
CTQYDKEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGI
FETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGMAAI
VEKKREDQGLEHLKITVGVDGTLYKLHPHFSRVLQETVEDLAPQCDVTFMLSEDGSGKGA
ALITAVAKRLQ
NT seq 2736 nt NT seq  +upstreamnt  +downstreamnt
atgttcgcggtacacttgatggcattttacttcaccaagctaaaggaggatcagatcaag
aaggtggacaggttcctgtatcacatgcggctctcagatgagaccctcttggacatcatg
gcccggttccaagctgagatggagaaaggtctagggaaggacacgaaccccacggcctcg
gtgaagatgctgcccaccttcgtcagggccattccagatggttcagaaaacggggagttc
ctttccctggatctgggaggttctaagtttcgagtattgaaggtgcaagtctctgaagag
gggaagcgacaggtccaaatggagagtcagttctacccaacgcccaatgagatcatccgg
gggaatggcatggagctctttgactatgtggctgactgcctggcagacttcatgaagacc
aaagagctgacacacaagaaactgccccttggctttaccttttcttttccctgcagacag
accaagttggaagagggcgtcctgctttcatggaccaagaagttcaaggcccggggggtt
caggatacagatgtggtgagccgcctgaccaacgccatgaagaggcacaaggacctggac
gtggatatcctggctttggtcaatgacaccgtggggaccatgatgacatgtgcctatgat
gatccctactgtgaagtcggcgtcatcatcggaacaggcaccaatgcatgctacatggag
gacatgagcaacatcgacctagtggaaggtgacgaggggaggatgtgcatcaacacagag
tggggggcctttggggacgacggggctttggaggacatccgcacagagtttgacagggag
ctggaccttggctcgatcaaccctgggaagcaactgttcgagaagatgatcagtggcctg
tacatgggggaactggtcaggctcatcttgctgaagatggccaaggctggcctcctgttt
gggggtgcaaaatcctccgctctccttatgaagggcaagattgaaacacagcacgtggct
gccatggagaggtataaagaaggcctggccaacacgagggagatcttagtggatctgggc
ctggacccctcagaggctgactgcattgcagtccagcacgtctgcaccatcgtctctttc
cgctctgccaatctttgtgctgctgctctggcagccatcctgacccgcctccagcaaaac
aagaagcaggcccggctccgtaccacagtgggcatggatggaactctctacaagatacat
cctcagtaccccaaacgcctgcacaaggtggtgaggaaactggtcccaaactgtgatgtc
cgcttcctcctatcagagagtggcagcaccaagggggccgctatggtgactgcagtggcc
tcccgagtgcaggcccagcgtaagcagattgacaaggtgctagctctgttccagctgact
caagagcaacttctgagtgttcgggacaggatgcggactgaacttgagtatgggctgaaa
aaaaaaactcatgccctggctacagtcaagatgttgcccacctatgtctacgggatgcct
gatggcacagagaaaggaaagtttctggctctggatttgggaggaactaacttccgggtc
cttctggtgaagatccgaagtggacggaggtcagtgcgaatgtacaacaagatctttgcc
atccctctggagatcatgcagggtactggtgaggagctgttcgatcatattgtgcagtgc
attgctgacttcctggagtacatgggcctcaagggagcccagctacctctgggcttcacg
ttctcctttccctgtagacagatgagcatcgacaagggaacactcgtagggtggaccaaa
ggcttcaaggctactgactgtgagggggaggacgtggtggacatgctcagagaagctatc
aagaggagaaatgagtttgacctggacatagttgcattggtgaatgacacggtggggacc
atgatgacctgtggctatgaagatcctaagtgtgaaattggcttgattgcagggaccgga
agcaatgtatgctacatggaggagatgaggaacatcgagctggtggaaggggatgaaggg
aagatgtgcatcaacacagagtggggtggatttggagataatggctgcatagatgatatt
tgcactcagtatgacaaggaggtggatgagggatccttgaatcctggcaagcagagatac
gagaaaatgaccagcgggatgtacctgggtgagattgtgcggcagatcctgatagacctg
accaagcaggggctcctcttccgaggacagatttcagagcgactccggaccaggggcatc
tttgaaaccaaattcctgtcccagattgaaagtgatcggctggccctcctgcaggtcaga
aggatcctgcagcagctgggcctggacagtacatgtgaagacagcattgtggtgaaggag
gtgtgtggggctgtgtcccggcgggcggcccagctctgtggtgcaggcatggctgccatt
gtggaaaagaagagagaggaccaggggctggagcacctgaagatcaccgtgggtgtggat
ggcacgctgtacaagctgcaccctcacttctctcgagttctgcaggagacagtggaagat
ctggcccctcagtgtgacgtgacattcatgttgtcagaggacggcagtgggaagggagcg
gctttgatcactgcagtagccaagaggttacagtag

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