KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103739378
Entry
103739378         CDS       T03372                                 

Gene name
Cacna1c
Definition
(RefSeq) calcium voltage-gated channel subunit alpha1 C
  KO
K04850  voltage-dependent calcium channel L type alpha-1C
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi04010  MAPK signaling pathway
ngi04020  Calcium signaling pathway
ngi04022  cGMP-PKG signaling pathway
ngi04024  cAMP signaling pathway
ngi04260  Cardiac muscle contraction
ngi04261  Adrenergic signaling in cardiomyocytes
ngi04270  Vascular smooth muscle contraction
ngi04713  Circadian entrainment
ngi04720  Long-term potentiation
ngi04723  Retrograde endocannabinoid signaling
ngi04724  Glutamatergic synapse
ngi04725  Cholinergic synapse
ngi04726  Serotonergic synapse
ngi04727  GABAergic synapse
ngi04728  Dopaminergic synapse
ngi04742  Taste transduction
ngi04911  Insulin secretion
ngi04912  GnRH signaling pathway
ngi04921  Oxytocin signaling pathway
ngi04924  Renin secretion
ngi04925  Aldosterone synthesis and secretion
ngi04927  Cortisol synthesis and secretion
ngi04929  GnRH secretion
ngi04930  Type II diabetes mellitus
ngi04934  Cushing syndrome
ngi04935  Growth hormone synthesis, secretion and action
ngi05010  Alzheimer disease
ngi05020  Prion disease
ngi05022  Pathways of neurodegeneration - multiple diseases
ngi05031  Amphetamine addiction
ngi05410  Hypertrophic cardiomyopathy
ngi05412  Arrhythmogenic right ventricular cardiomyopathy
ngi05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ngi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103739378 (Cacna1c)
   04020 Calcium signaling pathway
    103739378 (Cacna1c)
   04024 cAMP signaling pathway
    103739378 (Cacna1c)
   04022 cGMP-PKG signaling pathway
    103739378 (Cacna1c)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    103739378 (Cacna1c)
   04929 GnRH secretion
    103739378 (Cacna1c)
   04912 GnRH signaling pathway
    103739378 (Cacna1c)
   04921 Oxytocin signaling pathway
    103739378 (Cacna1c)
   04935 Growth hormone synthesis, secretion and action
    103739378 (Cacna1c)
   04924 Renin secretion
    103739378 (Cacna1c)
   04925 Aldosterone synthesis and secretion
    103739378 (Cacna1c)
   04927 Cortisol synthesis and secretion
    103739378 (Cacna1c)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    103739378 (Cacna1c)
   04261 Adrenergic signaling in cardiomyocytes
    103739378 (Cacna1c)
   04270 Vascular smooth muscle contraction
    103739378 (Cacna1c)
  09156 Nervous system
   04724 Glutamatergic synapse
    103739378 (Cacna1c)
   04727 GABAergic synapse
    103739378 (Cacna1c)
   04725 Cholinergic synapse
    103739378 (Cacna1c)
   04728 Dopaminergic synapse
    103739378 (Cacna1c)
   04726 Serotonergic synapse
    103739378 (Cacna1c)
   04720 Long-term potentiation
    103739378 (Cacna1c)
   04723 Retrograde endocannabinoid signaling
    103739378 (Cacna1c)
  09157 Sensory system
   04742 Taste transduction
    103739378 (Cacna1c)
  09159 Environmental adaptation
   04713 Circadian entrainment
    103739378 (Cacna1c)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103739378 (Cacna1c)
   05020 Prion disease
    103739378 (Cacna1c)
   05022 Pathways of neurodegeneration - multiple diseases
    103739378 (Cacna1c)
  09165 Substance dependence
   05031 Amphetamine addiction
    103739378 (Cacna1c)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    103739378 (Cacna1c)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    103739378 (Cacna1c)
   05414 Dilated cardiomyopathy
    103739378 (Cacna1c)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    103739378 (Cacna1c)
   04934 Cushing syndrome
    103739378 (Cacna1c)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:ngi04040]
    103739378 (Cacna1c)
Ion channels [BR:ngi04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   103739378 (Cacna1c)
SSDB
Motif
Pfam: Ion_trans CAC1F_C GPHH Ca_chan_IQ PKD_channel Etmic-2
Other DBs
NCBI-GeneID: 103739378
NCBI-ProteinID: XP_017655291
LinkDB
Position
Un
AA seq 2189 aa
MVNENTRMYVPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAAR
QAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGGTTATRPPRALLCLTLKNPIRRACISI
VEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIA
YGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFR
VLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYN
QEGIVDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCI
TMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGD
FQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVA
GGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNIFYWLVIFLVFLNTLT
IASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGI
LETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFL
FIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG
GPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLAR
TASPEKKPEVVEKKPAVEETKEEKIELKSITADGESPPTTKINMDDLQPSENEDKGPYSN
PDATGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVND
TIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYV
FTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSVINVVKILXV
LRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS
DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPE
LLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN
CELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQ
HYGQSCLFKIAMNILNMLFTGLFTVEMILKFIAFKPKGYFSDPWNVFDFLIVIGSIIDVI
LSETNHYFCDAWNTFDALIVVGSIVDKAITKVHPAEHTQCSPSMSAEENSRISITFFRLF
RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKISLNDTT
EINQNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPGNSTEGEMPCGSSF
AVFYFISFYMLCAFLIISLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGR
IKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRIALR
IKSEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFWKF
KKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAAS
EDDIFRRAGGLFGNHVTYYPSDSRNTFPQTFTTQRPLHINKTGNNQGDTESPSHEKLVDS
TFTPSSYSSTGSNANINNANNTALGHFPHPTSYSSTVSTMEGHGPPLSPAIRVQEAAWKL
SSKRCHSRESQGAMVSREEVLPDETCTVRIGEDTEYCSEPSLLSTEMLSYQDDEHRQLAS
LEEDKREIRQSPKRSFLRSASLGRRASFHLECLKRQKNQGGDISQKTVLPLHLVHHQALA
VAGLSPLLQRSHSPTTFPRPCPTPPVTPGNLGRPLQPIPTLRLEGAESSEKLNSSFPSIH
CSSWSEETTACSGGSSMARRARPVSLTVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFA
QDPKFIEVTTQELADACDMTIEEMENAADNILSGGTQQNPNGTLLPFVNCRDPGEDRAGV
PEDESCAFALGRGRSEEALADSRAFVSNL
NT seq 6570 nt   +upstreamnt  +downstreamnt
atggtcaatgaaaacaccaggatgtacgttccggaggaaaaccaccaaggttccaactat
gggagcccacgcccagcccatgccaacatgaatgccaatgcagcagcggggctcgcccct
gagcacatccctactccaggggcagccctgtcctggcaggcagccatcgatgccgcccgg
caggccaagctgatgggcagtgctggcaatgcgaccatctctacggtcagctccacacag
cggaagcggcagcagtatgggaaacccaagaagcagggtggtacgaccgccacacggccg
ccccgtgccctgctctgcctgactctgaagaaccctatcaggagggcatgcatcagcatc
gttgaatggaaaccatttgaaataattattttactgactatttttgccaattgtgtggcc
ttagcaatctatattcccttcccagaagatgactccaacgccaccaactccaacctggaa
cgagtggaatatctctttctcataatttttaccgtggaagcatttttaaaagtaattgcc
tatggacttctctttcaccccaacgcttacctccgcaatggttggaatttactagatttt
ataattgtggttgtagggctttttagtgcaattttagaacaagcaaccaaagctgatggg
gccaatgctctaggagggaaaggagctggattcgatgtgaaggcactgagggctttccga
gttctgcgtcccctgcggctggtgtctggagtcccaagtctccaggtggtcctgaactcc
atcatcaaggccatggtgcctctgctgcacattgccttgcttgtgctgttcgtcatcatc
atctacgccatcatcggcctggagctcttcatgggaaagatgcataagacctgctacaac
caggagggcatagtagatgttccagcagaagaggacccttctccttgtgctttggagaca
ggccatgggcggcagtgtcagaatgggaccgtgtgcaagcccgggtgggatgggcccaag
cacggcatcaccaacttcgacaacttcgcctttgccatgctgacagtgttccagtgcatc
accatggagggctggacagatgtgctatactgggtcaatgatgccgtaggaagggactgg
ccctggatctattttgttacactaatcatcatagggtcattttttgtacttaacttggtt
ctcggtgttcttagcggagagttttccaaagagagggagaaggccaaggctcggggagat
ttccagaagcttcgagagaagcagcagctagaagaagatctcaaaggctacctggactgg
atcacccaggcagaagacattgaccctgagaacgaggatgagggcatggatgaagaaaag
ccccgcaacatgagcatgcccacaagtgagactgaatctgtcaacactgaaaatgtggct
ggaggtgacatcgagggcgaaaactgtggagccagactggcccaccggatctccaaatcc
aagttcagccgctactggcgcaggtggaaccgattctgcagaagaaagtgtcgtgcagcc
gtcaagtccaacatcttctactggcttgtgatcttccttgtgttcctcaatacactcacc
attgcctctgaacattacaaccagccccactggctcacagaagtgcaagacacagccaat
aaggccctcctggccctttttactgcagaaatgctcctgaagatgtatagcctaggcctg
caggcctatttcgtatccctcttcaaccgctttgactgcttcatcgtgtgtgggggcatc
ctggagaccatcctggtggagaccaaaatcatgtctcccttgggcatctctgtgctgaga
tgtgtacggctgctcaggatctttaagatcaccaggtactggaactccttgagcaacctc
gtggcatccttgctgaactctgtccgctccattgcctccctgttgcttctccttttcctc
ttcatcatcatcttctcccttctggggatgcagctgtttggaggaaagttcaactttgat
gagatgcagacacgcaggagcacctttgataacttcccgcagtccctcctcactgtgttt
cagatcctgaccggggaggactggaattcggtgatgtatgatgggatcatggcttatggc
ggcccctcttttccagggatgttagtctgtatttacttcatcatcctcttcatctgtgga
aactatatcctactgaatgtgttcttggccattgcggtggacaatctggctgatgcggag
agcctcacctctgcacaaaaggaggaagaagaagagaaagagagaaagaagctggccagg
actgccagcccagagaagaagccggaggtggtagagaagaagccagcggtggaggagacc
aaggaggagaaaattgaactgaagtccattactgcagatggagagtccccacccaccacc
aagatcaacatggatgacctccaacccagtgaaaatgaggataagggtccctactccaac
ccagatgccacaggagaagaggatgaggaggagcctgagatgcctgtggggccacgccct
cggcccctgtctgagctgcaccttaaggaaaaggcagtgcccatgcctgaagccagtgca
tttttcatctttagccccaacaacaggtttcgcctccagtgccaccgcattgtcaatgac
acgatcttcaccaacctgatcctcttcttcattttgctcagcagcatctctctggctgct
gaggaccccgtccagcacacctccttcaggaaccatattctgttttattttgacattgtt
ttcactaccattttcaccattgaaattgctctgaagatcctaggcaatgcagactatgtc
ttcactagtatctttacattagaaattatccttaagatgactgcttatggggctttcctg
cacaagggctctttctgccgaaattacttcaacatcctggacctgctggtggtcagcgtg
tccctcatctcttttggcatccagtccagtgtgatcaacgttgtgaagatcttataagtg
cttcgagtcctcaggcccctcagggccatcaacagagccaaggggctaaagcatgtagta
cagtgtgtgtttgtggccatccggaccatcgggaacattgtaattgtcaccacgctgctg
cagttcatgttcgcctgcattggagtccagctcttcaagggaaaactctacacctgttca
gatagttccaaacagacagaggcagaatgcaagggtaactatatcacatataaagatgga
gaggttgaccatcccattatccagccccgcagctgggagaacagcaagtttgactttgac
aatgttctggcagccatgatggccctcttcactgtctccacctttgaggggtggccagag
ctgctgtatcgctccatcgactcccacacagaagacaagggccccatctacaactaccgt
gtggagatctccatcttcttcatcatttacatcatcatcatcgcctttttcatgatgaac
atctttgtgggtttcgtcatcgtcaccttccaagagcaaggggaacaagagtacaagaac
tgtgagctggacaagaaccagcgacagtgtgtagaatacgccctcaaggcccgacccctg
cggaggtacatccccaagaaccagcaccagtacaaagtgtggtatgtggtcaactctacc
tacttcgagtatctgatgttcgttctcatcctgctcaacaccatctgcctggccatgcag
cactatggccagagctgcctgttcaaaattgccatgaacatactcaacatgctcttcact
ggcctcttcactgtggagatgatcctgaagttcattgccttcaaacccaagggttacttt
agtgatccctggaatgtttttgacttcctcatcgtgattgggagcataattgatgtcatt
ctcagtgagactaatcactatttctgtgatgcatggaatacatttgacgccttgattgtt
gtgggtagcattgttgataaagcaatcaccaaggtacacccagctgaacatacccaatgc
tctccctctatgagtgcagaggagaactcccgcatctccatcaccttcttccgcctcttc
cgggtcatgcgcctggtgaaactgctgagccgcggagaaggcatccggaccctgctgtgg
accttcatcaagtccttccaggccctgccctatgtggcccttctgattgtgatgctgttc
tttatctatgcagtgattgggatgcaggtgtttgggaagatttccctgaatgacaccaca
gagatcaatcagaacaacaacttccagaccttccctcaagctgtgctactgctcttcagg
tgtgccactggggaggcctggcaggacatcatgctggcctgcatgccaggcaagaagtgt
gccccagagtcagagcccggcaacagcacagaaggagagatgccctgtggcagcagtttt
gctgtcttctatttcatcagcttctacatgctctgtgccttcctgatcatcagcctcttt
gtagctgttatcatggacaactttgactacctgacaagggattggtctatccttggtccc
catcatctggatgaatttaaaagaatctgggcagagtatgaccctgaagccaagggtcgg
atcaaacacttggatgtggtgaccctcctccgaaggattcagccgcccctgggctttggg
aagctgtgtcctcaccgtgtggcctgcaaacgcctggtctccatgaatatgcctctgaac
agcgatgggacagtcatgttcaatgccaccctgtttgccctggtcaggatagccctgagg
attaaatcagaagggaacctagaacaagccaatgaggagctgcgagccatcataaagaag
atctggaagaggaccagcatgaagctgctggaccaggtggtgccccctgcaggcgatgat
gaggtcacagtaggcaagttttatgctactttcctgatccaagagtacttctggaaattc
aagaagcgcaaagagcagggactggtgggcaagccctcgcagaggaacgcactatccctg
caggctggcttgcgcacgctgcatgacattggtcctgagatccgccgggccatctctgga
gatctgactgctgaggaggagctggacaaagccatgaaggaggctgtgtctgctgcctcc
gaagatgacatcttcaggagggccggaggcctgtttggcaaccacgtcacctactatcca
agtgacagcaggaatacctttccccagaccttcaccacccagcgcccactgcatatcaac
aagaccggaaacaaccaaggtgacaccgagtcgccatcccatgagaaacttgtggactcc
acgttcacccccagtagctactcatccactggctccaatgccaacatcaacaacgccaac
aacactgccttgggccactttccccaccccaccagctactccagcacagtcagcactatg
gagggccatgggcctcccttgtctcctgctatccgagtacaggaggcagcatggaagctc
agttccaagaggtgccactcacgagagagccagggagccatggtgagtagggaggaggta
ttaccagatgagacgtgcacggtgcggatcggtgaagatactgagtactgcagcgagccc
agcctgctctccacagagatgctctcctaccaggatgatgaacatcgacaactagcatct
ctagaggaggacaagagggagatccggcagtctccaaagaggagtttccttcgctctgcc
tctcttggtcgaagggcttccttccacctggaatgtctgaagcgacaaaagaatcaaggg
ggagatatctctcagaagacagtcctgcccttgcatctggttcatcatcaggcgttggca
gtggcaggcttgagccccctcctacagagaagccattcccctaccacattccccaggcca
tgccccacgccccctgtcactccaggcaacctgggcaggcccctgcagcccatccccacc
ctacggctggagggggctgagtccagcgagaaactcaatagcagcttcccatccatccac
tgcagctcctggtctgaggagaccactgcctgtagtgggggcagcagcatggcccggaga
gcccggcctgtctccctcactgtgcccagccaggctggagctcctggaagacagttccac
ggcagtgccagcagcctggtggaagcggtcttgatttctgaaggactggggcagttcgct
caagatcccaagttcatcgaggtcactacccaggagctggctgatgcctgcgacatgacg
atagaggagatggagaatgccgcagacaacatcctcagtgggggcacccagcagaacccc
aatggcaccctcttaccttttgtgaactgcagggaccccggggaggacagggctggggtc
ccggaggacgagagctgtgcatttgccctgggccggggccgcagcgaggaggcgctcgcg
gacagtagggccttcgtcagcaacctgtag

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