KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103745559
Entry
103745559         CDS       T03372                                 

Gene name
Ptpn11
Definition
(RefSeq) protein tyrosine phosphatase, non-receptor type 11
  KO
K07293  tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi04014  Ras signaling pathway
ngi04072  Phospholipase D signaling pathway
ngi04360  Axon guidance
ngi04625  C-type lectin receptor signaling pathway
ngi04630  JAK-STAT signaling pathway
ngi04650  Natural killer cell mediated cytotoxicity
ngi04670  Leukocyte transendothelial migration
ngi04722  Neurotrophin signaling pathway
ngi04920  Adipocytokine signaling pathway
ngi04931  Insulin resistance
ngi05168  Herpes simplex virus 1 infection
ngi05205  Proteoglycans in cancer
ngi05211  Renal cell carcinoma
ngi05220  Chronic myeloid leukemia
ngi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ngi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    103745559 (Ptpn11)
   04630 JAK-STAT signaling pathway
    103745559 (Ptpn11)
   04072 Phospholipase D signaling pathway
    103745559 (Ptpn11)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    103745559 (Ptpn11)
   04650 Natural killer cell mediated cytotoxicity
    103745559 (Ptpn11)
   04670 Leukocyte transendothelial migration
    103745559 (Ptpn11)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    103745559 (Ptpn11)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    103745559 (Ptpn11)
  09158 Development and regeneration
   04360 Axon guidance
    103745559 (Ptpn11)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    103745559 (Ptpn11)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103745559 (Ptpn11)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    103745559 (Ptpn11)
   05211 Renal cell carcinoma
    103745559 (Ptpn11)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    103745559 (Ptpn11)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    103745559 (Ptpn11)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:ngi01009]
    103745559 (Ptpn11)
Enzymes [BR:ngi01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     103745559 (Ptpn11)
Protein phosphatases and associated proteins [BR:ngi01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    103745559 (Ptpn11)
SSDB
Motif
Pfam: Y_phosphatase SH2 DSPc Y_phosphatase3 PTPlike_phytase
Other DBs
NCBI-GeneID: 103745559
NCBI-ProteinID: XP_008845726
LinkDB
Position
Un
AA seq 593 aa
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
NT seq 1782 nt   +upstreamnt  +downstreamnt
atgacatcccggagatggtttcacccaaacatcactggtgtggaggcagaaaatctcctg
ttgaccagaggagtcgatggcagttttttggccaggcccagtaaaagtaaccctggagac
ttcactctgtccgttagaagaaatggagctgtcacccacatcaagattcagaacactggt
gactactacgacctgtatggcggggaaaagtttgccaccttggctgagctggtccagtat
tacatggaacaccatgggcagttgaaagagaagaatggagatgtcattgagctcaaatat
ccactgaactgtgcagatcctacctctgaaaggtggttccatggtcacctgtctggaaaa
gaagcagagaagctactaacggagaaggggaagcatggcagctttcttgtccgggagagc
cagagccaccctggcgacttcgttctctcagttcgcacaggtgacgacaaaggggagagc
aacgatggcaagtccaaagtgacccacgtcatgatccgctgtcaggagctgaaatatgat
gttggtggaggagagcggtttgactctttgacagacctggtggagcattacaagaagaat
cccatggtagaaacgctgggtacagtactgcagctcaagcagcccctcaacacaactcgt
attaatgctgctgaaattgaaagccgggttcgagagctaagcaaactagctgagaccaca
gataaagtcaaacagggcttttgggaagaatttgagacactacaacaacaggagtgcaaa
cttctctacagccgcaaagaaggtcagaggcaagaaaataaaaacaaaaacagatacaaa
aacatcctaccctttgatcataccagggttgtcctgcatgatggggatcctaatgagcca
gtttccgattacatcaacgcaaatatcatcatgcctgaatttgaaaccaagtgcaacaat
tcaaagcccaaaaagagttacattgctacacaaggctgcctgcaaaatacggtgaatgac
ttctggcggatggtgttccaggagaactcccgagtcattgttatgaccacaaaggaggtg
gaaagaggaaagagcaaatgtgtcaagtactggcctgatgagtatgcactcaaagaatat
ggagttatgcgtgttaggaacgtcaaagaaagtgctgctcatgactacaccttaagagaa
ctgaaactctccaaggtcggacaagggaatacggagagaaccgtctggcaataccacttt
cggacctggccggaccatggtgtgcccagtgaccccggaggcgtactggatttcctggag
gaggtccaccacaagcaggagagcatcatggacgcaggccctgttgtggttcactgcagt
gctggaattggccggacagggacgttcattgtgatcgatatccttattgacatcatcaga
gagaaaggtgttgactgtgacattgacgttcccaaaaccattcagatggtgaggtcccag
aggtcagggatggtccagacagaagcacagtaccgtttcatctacatggccgtccaacat
tatattgaaacgctgcagcgcagaattgaggaggagcagaaaagcaagaggaaagggcat
gaatataccaatattaagtattccctcgcggaccagacaagtggtgatcagagtcccctg
ccgccttgcaccccaacaccaccctgtgcggaaatgagggaagacagcgctagagtctat
gagaacgtgggcctgatgcagcagcagaagagcttcagatga

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