KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103751075
Entry
103751075         CDS       T03372                                 

Gene name
Hras
Definition
(RefSeq) HRas proto-oncogene, GTPase
  KO
K02833  GTPase HRas
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi01521  EGFR tyrosine kinase inhibitor resistance
ngi01522  Endocrine resistance
ngi04010  MAPK signaling pathway
ngi04012  ErbB signaling pathway
ngi04014  Ras signaling pathway
ngi04015  Rap1 signaling pathway
ngi04062  Chemokine signaling pathway
ngi04068  FoxO signaling pathway
ngi04071  Sphingolipid signaling pathway
ngi04072  Phospholipase D signaling pathway
ngi04137  Mitophagy - animal
ngi04140  Autophagy - animal
ngi04144  Endocytosis
ngi04150  mTOR signaling pathway
ngi04151  PI3K-Akt signaling pathway
ngi04210  Apoptosis
ngi04211  Longevity regulating pathway
ngi04213  Longevity regulating pathway - multiple species
ngi04218  Cellular senescence
ngi04360  Axon guidance
ngi04370  VEGF signaling pathway
ngi04371  Apelin signaling pathway
ngi04510  Focal adhesion
ngi04540  Gap junction
ngi04550  Signaling pathways regulating pluripotency of stem cells
ngi04625  C-type lectin receptor signaling pathway
ngi04630  JAK-STAT signaling pathway
ngi04650  Natural killer cell mediated cytotoxicity
ngi04660  T cell receptor signaling pathway
ngi04662  B cell receptor signaling pathway
ngi04664  Fc epsilon RI signaling pathway
ngi04714  Thermogenesis
ngi04720  Long-term potentiation
ngi04722  Neurotrophin signaling pathway
ngi04725  Cholinergic synapse
ngi04726  Serotonergic synapse
ngi04730  Long-term depression
ngi04810  Regulation of actin cytoskeleton
ngi04910  Insulin signaling pathway
ngi04912  GnRH signaling pathway
ngi04915  Estrogen signaling pathway
ngi04916  Melanogenesis
ngi04917  Prolactin signaling pathway
ngi04919  Thyroid hormone signaling pathway
ngi04921  Oxytocin signaling pathway
ngi04926  Relaxin signaling pathway
ngi04929  GnRH secretion
ngi04933  AGE-RAGE signaling pathway in diabetic complications
ngi04935  Growth hormone synthesis, secretion and action
ngi05010  Alzheimer disease
ngi05022  Pathways of neurodegeneration - multiple diseases
ngi05034  Alcoholism
ngi05132  Salmonella infection
ngi05160  Hepatitis C
ngi05161  Hepatitis B
ngi05163  Human cytomegalovirus infection
ngi05165  Human papillomavirus infection
ngi05166  Human T-cell leukemia virus 1 infection
ngi05167  Kaposi sarcoma-associated herpesvirus infection
ngi05170  Human immunodeficiency virus 1 infection
ngi05200  Pathways in cancer
ngi05203  Viral carcinogenesis
ngi05205  Proteoglycans in cancer
ngi05206  MicroRNAs in cancer
ngi05210  Colorectal cancer
ngi05211  Renal cell carcinoma
ngi05213  Endometrial cancer
ngi05214  Glioma
ngi05215  Prostate cancer
ngi05216  Thyroid cancer
ngi05218  Melanoma
ngi05219  Bladder cancer
ngi05220  Chronic myeloid leukemia
ngi05221  Acute myeloid leukemia
ngi05223  Non-small cell lung cancer
ngi05224  Breast cancer
ngi05225  Hepatocellular carcinoma
ngi05226  Gastric cancer
ngi05230  Central carbon metabolism in cancer
ngi05231  Choline metabolism in cancer
ngi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ngi05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ngi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103751075 (Hras)
   04012 ErbB signaling pathway
    103751075 (Hras)
   04014 Ras signaling pathway
    103751075 (Hras)
   04015 Rap1 signaling pathway
    103751075 (Hras)
   04370 VEGF signaling pathway
    103751075 (Hras)
   04371 Apelin signaling pathway
    103751075 (Hras)
   04630 JAK-STAT signaling pathway
    103751075 (Hras)
   04068 FoxO signaling pathway
    103751075 (Hras)
   04072 Phospholipase D signaling pathway
    103751075 (Hras)
   04071 Sphingolipid signaling pathway
    103751075 (Hras)
   04151 PI3K-Akt signaling pathway
    103751075 (Hras)
   04150 mTOR signaling pathway
    103751075 (Hras)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    103751075 (Hras)
   04140 Autophagy - animal
    103751075 (Hras)
   04137 Mitophagy - animal
    103751075 (Hras)
  09143 Cell growth and death
   04210 Apoptosis
    103751075 (Hras)
   04218 Cellular senescence
    103751075 (Hras)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103751075 (Hras)
   04540 Gap junction
    103751075 (Hras)
   04550 Signaling pathways regulating pluripotency of stem cells
    103751075 (Hras)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103751075 (Hras)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    103751075 (Hras)
   04650 Natural killer cell mediated cytotoxicity
    103751075 (Hras)
   04660 T cell receptor signaling pathway
    103751075 (Hras)
   04662 B cell receptor signaling pathway
    103751075 (Hras)
   04664 Fc epsilon RI signaling pathway
    103751075 (Hras)
   04062 Chemokine signaling pathway
    103751075 (Hras)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103751075 (Hras)
   04929 GnRH secretion
    103751075 (Hras)
   04912 GnRH signaling pathway
    103751075 (Hras)
   04915 Estrogen signaling pathway
    103751075 (Hras)
   04917 Prolactin signaling pathway
    103751075 (Hras)
   04921 Oxytocin signaling pathway
    103751075 (Hras)
   04926 Relaxin signaling pathway
    103751075 (Hras)
   04935 Growth hormone synthesis, secretion and action
    103751075 (Hras)
   04919 Thyroid hormone signaling pathway
    103751075 (Hras)
   04916 Melanogenesis
    103751075 (Hras)
  09156 Nervous system
   04725 Cholinergic synapse
    103751075 (Hras)
   04726 Serotonergic synapse
    103751075 (Hras)
   04720 Long-term potentiation
    103751075 (Hras)
   04730 Long-term depression
    103751075 (Hras)
   04722 Neurotrophin signaling pathway
    103751075 (Hras)
  09158 Development and regeneration
   04360 Axon guidance
    103751075 (Hras)
  09149 Aging
   04211 Longevity regulating pathway
    103751075 (Hras)
   04213 Longevity regulating pathway - multiple species
    103751075 (Hras)
  09159 Environmental adaptation
   04714 Thermogenesis
    103751075 (Hras)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103751075 (Hras)
   05206 MicroRNAs in cancer
    103751075 (Hras)
   05205 Proteoglycans in cancer
    103751075 (Hras)
   05203 Viral carcinogenesis
    103751075 (Hras)
   05230 Central carbon metabolism in cancer
    103751075 (Hras)
   05231 Choline metabolism in cancer
    103751075 (Hras)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103751075 (Hras)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103751075 (Hras)
   05225 Hepatocellular carcinoma
    103751075 (Hras)
   05226 Gastric cancer
    103751075 (Hras)
   05214 Glioma
    103751075 (Hras)
   05216 Thyroid cancer
    103751075 (Hras)
   05221 Acute myeloid leukemia
    103751075 (Hras)
   05220 Chronic myeloid leukemia
    103751075 (Hras)
   05218 Melanoma
    103751075 (Hras)
   05211 Renal cell carcinoma
    103751075 (Hras)
   05219 Bladder cancer
    103751075 (Hras)
   05215 Prostate cancer
    103751075 (Hras)
   05213 Endometrial cancer
    103751075 (Hras)
   05224 Breast cancer
    103751075 (Hras)
   05223 Non-small cell lung cancer
    103751075 (Hras)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103751075 (Hras)
   05170 Human immunodeficiency virus 1 infection
    103751075 (Hras)
   05161 Hepatitis B
    103751075 (Hras)
   05160 Hepatitis C
    103751075 (Hras)
   05163 Human cytomegalovirus infection
    103751075 (Hras)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103751075 (Hras)
   05165 Human papillomavirus infection
    103751075 (Hras)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    103751075 (Hras)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103751075 (Hras)
   05022 Pathways of neurodegeneration - multiple diseases
    103751075 (Hras)
  09165 Substance dependence
   05034 Alcoholism
    103751075 (Hras)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103751075 (Hras)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    103751075 (Hras)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103751075 (Hras)
   01522 Endocrine resistance
    103751075 (Hras)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ngi04131]
    103751075 (Hras)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:ngi04147]
    103751075 (Hras)
   04031 GTP-binding proteins [BR:ngi04031]
    103751075 (Hras)
Membrane trafficking [BR:ngi04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    103751075 (Hras)
Exosome [BR:ngi04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   103751075 (Hras)
  Exosomal proteins of colorectal cancer cells
   103751075 (Hras)
GTP-binding proteins [BR:ngi04031]
 Small (monomeric) G-proteins
  Ras Family
   Ras [OT]
    103751075 (Hras)
SSDB
Motif
Pfam: Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 FeoB_N Gtr1_RagA G-alpha ATP_bind_1 Septin Ldh_1_N AAA_16
Other DBs
NCBI-GeneID: 103751075
NCBI-ProteinID: XP_008852607
LinkDB
Position
Un
AA seq 189 aa
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
NT seq 570 nt   +upstreamnt  +downstreamnt
atgacagaatacaagcttgtagtggtgggcgctggaggtgtggggaagagtgccttgacc
atccagctgatccagaaccactttgtggatgagtatgatcccaccatagaggactcttac
cggaaacaggtagttattgatggggagacatgtctactggacatcttggacacagcaggc
caagaggagtatagtgccatgcgggaccagtacatgcgcacaggggagggcttcctctgt
gtgtttgccatcaacaataccaagtcctttgaagacatccatcagtacagggagcagatc
aagcgggtgaaggactcggacgatgtgccaatggtgctggtggggaacaagtgtgacctg
gctgctcgtactgtcgagtctcggcaggcccaggaccttgcccgcagctacggcatcccc
tacattgaaacatcagccaagacccggcagggtgtggaggatgccttctacacgctagtg
cgtgagattcggcagcataaattacggaagctgaacccaccagatgagagtggccctggc
tgcatgagctgcaaatgtgtgctatcctga

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